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csgE curli assembly component CsgE [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945711, updated on 4-Feb-2026
Official Symbol
csgE
Official Full Name
curli assembly component CsgE
Primary source
ECOCYC:G6545
Locus tag
b1039
See related
ASAP:ABE-0003528
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1025
Summary
Probable periplasmic protein with predicted 22 aa signal. [More information is available at EcoGene: EG13411]. An insertion in the csgE gene abolishes the formation of curli, although csgA, which encodes one of the structural subunits of curli, continues to be expressed. [More information is available at EcoCyc: G6545].
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Sequence:
NC_000913.3 (1102152..1102541, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene curli secretion channel Neighboring gene curli assembly component CsgF Neighboring gene DNA-binding transcriptional dual regulator CsgD Neighboring gene curlin, minor subunit

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Solution NMR structure of CsgE: Structural insights into a chaperone and regulator protein important for functional amyloid formation. Shu Q, et al. Proc Natl Acad Sci U S A, 2016 Jun 28. PMID 27298344, Free PMC Article
  2. Continuous and pulsed hydrogen-deuterium exchange and mass spectrometry characterize CsgE oligomerization. Wang H, et al. Biochemistry, 2015 Oct 27. PMID 26418947, Free PMC Article
  3. Structure-Function Analysis of the Curli Accessory Protein CsgE Defines Surfaces Essential for Coordinating Amyloid Fiber Formation. Klein RD, et al. mBio, 2018 Jul 17. PMID 30018113, Free PMC Article
  4. Structural and mechanistic insights into the bacterial amyloid secretion channel CsgG. Goyal P, et al. Nature, 2014 Dec 11. PMID 25219853, Free PMC Article
  5. Structural insights into functional amyloid inhibition in Gram -ve bacteria. Hawthorne W, et al. Biochem Soc Trans, 2016 Dec 15. PMID 27913673, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A region of positive charge formed by the confluence of the beta1-beta2 and beta3-alpha2 loops at the head of Curli transport specificity factor CsgE plays a key role in the CsgE-CsgA (amyloidogenic CsgA) interaction and is required for curli assembly. These mechanistic insights into the directed assembly of functional amyloids in extracellular biofilms elucidate possible targets for biofilm-associated bacterial infect...
    Title: Structure-Function Analysis of the Curli Accessory Protein CsgE Defines Surfaces Essential for Coordinating Amyloid Fiber Formation.
  2. The electro-negative and flexible tail of CsgE can adjust toward the electro-positive patches on the CsgG interface as the initial step in binding.
    Title: Solution NMR structure of CsgE: Structural insights into a chaperone and regulator protein important for functional amyloid formation.
  3. Studies show the common structural features of CsgC and CsgE and the potential implications for general inhibition of amyloid.
    Title: Structural insights into functional amyloid inhibition in Gram -ve bacteria.
  4. determined regions involved in CsgE self-association and on the basis of that, prepared a double mutant W48A/F79A, derived from interface alanine scan, and verified that it exists as a monomer
    Title: Continuous and pulsed hydrogen-deuterium exchange and mass spectrometry characterize CsgE oligomerization.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within curli assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in curli assembly NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within protein secretion by the type VIII secretion system IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein secretion by the type VIII secretion system NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in protein transmembrane transport NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in single-species biofilm formation NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cell outer membrane IDA
Inferred from Direct Assay
more info
 PubMed 
part_of curli secretion complex IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
curli assembly component CsgE

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1102152..1102541 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415557.1 curli assembly component CsgE

    See identical proteins and their annotated locations for NP_415557.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A8S0FXW2
    Conserved Domains (1) summary
    PRK10386
    Location:1 → 129
    PRK10386; curli production assembly/transport protein CsgE
Nucleotide Protein
Heading Accession and Version

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