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icd isocitrate dehydrogenase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945702, updated on 19-Sep-2024

Summary

Official Symbol
icd
Official Full Name
isocitrate dehydrogenase
Primary source
ECOCYC:EG10489
Locus tag
b1136
See related
ASAP:ABE-0003823
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1122; icdA; icdE
Summary
This icd allele has a C-terminus added during prophage e14 integration at codon 362, introducing 2 amino acid changes in icd. icdC encodes the original C-terminus of icd. [More information is available at EcoGene: EG10489]. There are marked differences in the properties of enzymes from different sources. [More information is available at EcoCyc: EG10489].
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Genomic context

Sequence:
NC_000913.3 (1195123..1196373)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene phosphatase NudJ Neighboring gene 23S rRNA pseudouridine(2457) synthase Neighboring gene ncRNA Neighboring gene putative SAM-dependent methyltransferase YmfD

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables NAD binding IEA
Inferred from Electronic Annotation
more info
 
enables guanosine tetraphosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
enables isocitrate dehydrogenase (NADP+) activity IDA
Inferred from Direct Assay
more info
PubMed 
enables isocitrate dehydrogenase (NADP+) activity IEA
Inferred from Electronic Annotation
more info
 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within electron transport chain IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in glyoxylate cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within tricarboxylic acid cycle IDA
Inferred from Direct Assay
more info
PubMed 
involved_in tricarboxylic acid cycle IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
isocitrate dehydrogenase
NP_415654.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1195123..1196373
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415654.1 isocitrate dehydrogenase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415654.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A5B9AN17, A0A5D8MS09, A0A8H9XRX7, A0A8S7JXI6
    Conserved Domains (1) summary
    PRK07006
    Location:8416
    PRK07006; isocitrate dehydrogenase; Reviewed