U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

rutB ureidoacrylate amidohydrolase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945699, updated on 23-Apr-2026
Official Symbol
rutB
Official Full Name
ureidoacrylate amidohydrolase
Primary source
ECOCYC:G6522
Locus tag
b1011
See related
ASAP:ABE-0003414
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1002; ycdL
Summary
NtrC regulon. [More information is available at EcoGene: EG13858]. Escherichia coli K-12 contains a previously undescribed pathway for pyrimidine degradation. [More information is available at EcoCyc: G6522].
Try the new Gene page
Try the new Transcripts and proteins table
Sequence:
NC_000913.3 (1072171..1072863, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative aminoacrylate hydrolase RutD Neighboring gene 3-aminoacrylate deaminase Neighboring gene pyrimidine monooxygenase RutA Neighboring gene DNA-binding transcriptional regulator RutR Neighboring gene fused DNA-binding transcriptional repressor/proline dehydrogenase/1-pyrroline-5-carboxylate dehydrogenase PutA

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Structural and Functional Characterization of the Ureidoacrylate Amidohydrolase RutB from Escherichia coli. Busch MR, et al. Biochemistry, 2023 Feb 7. PMID 36599150
  2. Comparative genomics reveals novel biochemical pathways. Piskur J, et al. Trends Genet, 2007 Aug. PMID 17555842
  3. A hidden metabolic pathway exposed. Osterman A. Proc Natl Acad Sci U S A, 2006 Apr 11. PMID 16595627, Free PMC Article
  4. The Rut pathway for pyrimidine degradation: novel chemistry and toxicity problems. Kim KS, et al. J Bacteriol, 2010 Aug. PMID 20400551, Free PMC Article
  5. Nitrogen regulatory protein C-controlled genes of Escherichia coli: scavenging as a defense against nitrogen limitation. Zimmer DP, et al. Proc Natl Acad Sci U S A, 2000 Dec 19. PMID 11121068, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Structural and Functional Characterization of the Ureidoacrylate Amidohydrolase RutB from Escherichia coli.
    Title: Structural and Functional Characterization of the Ureidoacrylate Amidohydrolase RutB from Escherichia coli.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides IDA
Inferred from Direct Assay
more info
 PubMed 
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in nitrogen utilization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in nitrogen utilization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within nitrogen utilization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within pyrimidine nucleobase catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in uracil catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in uracil catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within uracil catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Preferred Names
ureidoacrylate amidohydrolase

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1072171..1072863 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415531.2 ureidoacrylate amidohydrolase

    See identical proteins and their annotated locations for NP_415531.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0J2E7K8
    Conserved Domains (1) summary
    TIGR03614
    Location:3 → 228
    RutB; pyrimidine utilization protein B
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.