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mltD membrane-bound lytic murein transglycosylase D [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945694, updated on 6-Jul-2026
Official Symbol
mltD
Official Full Name
membrane-bound lytic murein transglycosylase D
Primary source
ECOCYC:EG10246
Locus tag
b0211
See related
ASAP:ABE-0000704
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
dniR; ECK0211; yafG
Summary
MltD has been shown to be a murein hydrolase using zymography, to cause lysis or osmotically-stabilized spheroplasts when overproduced, and to be inhibited by bulgecin (Dijkstra A.J., Rudd, K.E., and Keck, W., A new member of the transglycosylase family of Escherichia coli displays a Gram-positive hydrolase motif, in "The soluble lytic transglycolsylase family of Escherichia coli", A.J. [More information is available at EcoGene: EG10246]. MltD is a membrane-bound lytic murein transglycosylase. [More information is available at EcoCyc: EG10246].
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Sequence:
NC_000913.3 (232597..233955, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene endonuclease/exonuclease/phosphatase domain-containing protein YafD Neighboring gene putative S-adenosylmethionine-dependent methyltransferase Neighboring gene hydroxyacylglutathione hydrolase GloB Neighboring gene protein YkfO Neighboring gene putative S-adenosyl-L-methionine-dependent methyltransferase Neighboring gene ribonuclease HI

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Folding of a LysM domain: entropy-enthalpy compensation in the transition state of an ideal two-state folder. Nickson AA, et al. J Mol Biol, 2008 Jul 11. PMID 18538343, Free PMC Article
  2. Glycan strand cleavage by a lytic transglycosylase, MltD contributes to the expansion of peptidoglycan in Escherichia coli. Kaul M, et al. PLoS Genet, 2024 Feb. PMID 38422114, Free PMC Article
  3. Assigning protein functions by comparative genome analysis: protein phylogenetic profiles. Pellegrini M, et al. Proc Natl Acad Sci U S A, 1999 Apr 13. PMID 10200254, Free PMC Article
  4. Reactions of all Escherichia coli lytic transglycosylases with bacterial cell wall. Lee M, et al. J Am Chem Soc, 2013 Mar 6. PMID 23421439, Free PMC Article
  5. Susceptibility to antibiotics and beta-lactamase induction in murein hydrolase mutants of Escherichia coli. Korsak D, et al. Antimicrob Agents Chemother, 2005 Apr. PMID 15793119, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables lytic endotransglycosylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lytic endotransglycosylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables peptidoglycan lytic transglycosylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables peptidoglycan lytic transglycosylase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidoglycan lytic transglycosylase activity NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in peptidoglycan metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidoglycan metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in peptidoglycan metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
membrane-bound lytic murein transglycosylase D

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    232597..233955 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414747.1 membrane-bound lytic murein transglycosylase D

    See identical proteins and their annotated locations for NP_414747.1

    Status: REVIEWED

    Conserved Domains (1) summary
    PRK10783
    Location:1 → 452
    mltD; membrane-bound lytic murein transglycosylase D; Provisional
Nucleotide Protein
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