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mltD membrane-bound lytic murein transglycosylase D [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945694, updated on 6-Jun-2024

Summary

Gene symbol
mltD
Gene description
membrane-bound lytic murein transglycosylase D
Primary source
ASAP:ABE-0000704
Locus tag
b0211
See related
ECOCYC:EG10246
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
dniR; ECK0211; yafG
Summary
MltD has been shown to be a murein hydrolase using zymography, to cause lysis or osmotically-stabilized spheroplasts when overproduced, and to be inhibited by bulgecin (Dijkstra A.J., Rudd, K.E., and Keck, W., A new member of the transglycosylase family of Escherichia coli displays a Gram-positive hydrolase motif, in "The soluble lytic transglycolsylase family of Escherichia coli", A.J. [More information is available at EcoGene: EG10246]. MltD is a membrane-bound lytic murein transglycosylase. [More information is available at EcoCyc: EG10246].
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Genomic context

Sequence:
NC_000913.3 (232597..233955, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene endonuclease/exonuclease/phosphatase domain-containing protein YafD Neighboring gene putative S-adenosylmethionine-dependent methyltransferase Neighboring gene hydroxyacylglutathione hydrolase GloB Neighboring gene protein YkfO Neighboring gene putative S-adenosyl-L-methionine-dependent methyltransferase Neighboring gene ribonuclease HI

General gene information

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables lyase activity IEA
Inferred from Electronic Annotation
more info
 
enables lytic endotransglycosylase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables lytic endotransglycosylase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables lytic transglycosylase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables lytic transglycosylase activity IEA
Inferred from Electronic Annotation
more info
 
enables lytic transglycosylase activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in cell wall organization IEA
Inferred from Electronic Annotation
more info
 
involved_in peptidoglycan metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane NAS
Non-traceable Author Statement
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
membrane-bound lytic murein transglycosylase D

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    232597..233955 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414747.1 membrane-bound lytic murein transglycosylase D [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414747.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A9P2ICX7
    Conserved Domains (1) summary
    PRK10783
    Location:1452
    mltD; membrane-bound lytic murein transglycosylase D; Provisional