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hflD lysogenization regulator [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945693, updated on 6-May-2021

Summary

Gene symbol
hflD
Gene description
lysogenization regulator
Primary source
ASAP:ABE-0003812
Locus tag
b1132
See related
ECOCYC:EG11345
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1118; hslZ; ycfC
Summary
hflD is a non-essential gene. [More information is available at EcoGene: EG11345]. hflD belongs to an operon with purB, which is involved in methionine synthesis . hflD encodes an inner membrane-localized protein responsible for directly interacting with protein CII of bacteriophage , making it more vulnerable to proteolysis by FtsH, leading to increased lysogenization frequency of . [More information is available at EcoCyc: EG11345].
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Genomic context

Sequence:
NC_000913.3 (1191990..1192631, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene sensor histidine kinase PhoQ Neighboring gene DNA-binding transcriptional dual regulator PhoP Neighboring gene adenylosuccinate lyase Neighboring gene tRNA-specific 2-thiouridylase Neighboring gene phosphatase NudJ

Pathways from PubChem

General gene information

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within response to heat IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in extrinsic component of cytoplasmic side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extrinsic component of cytoplasmic side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1191990..1192631 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415650.1 lysogenization regulator [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415650.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P25746
    Conserved Domains (1) summary
    PRK00218
    Location:1209
    PRK00218; lysogenization regulator HflD
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