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lacA galactoside O-acetyltransferase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945674, updated on 6-Jul-2026
Official Symbol
lacA
Official Full Name
galactoside O-acetyltransferase
Primary source
ECOCYC:EG10524
Locus tag
b0342
See related
ASAP:ABE-0001177
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0339
Summary
LacA contains 8 hexapeptide repeats. [More information is available at EcoGene: EG10524]. Early work done on the protein identified it as a homodimer, however recent work has shown it to be a homotrimer. [More information is available at EcoCyc: EG10524].
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Sequence:
NC_000913.3 (361249..361860, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene cyanase Neighboring gene cyanate transporter Neighboring gene lactose permease Neighboring gene beta-galactosidase

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Coarse-graining the self-assembly of beta-helical protein building blocks. Curcó D, et al. J Phys Chem B, 2007 Dec 20. PMID 18027921
  2. Thiogalactoside transacetylase of the lactose operon as an enzyme for detoxification. Andrews KJ, et al. J Bacteriol, 1976 Oct. PMID 789355, Free PMC Article
  3. DNA sequence of the lactose operon: the lacA gene and the transcriptional termination region. Hediger MA, et al. Proc Natl Acad Sci U S A, 1985 Oct. PMID 3901000, Free PMC Article
  4. The amino acid sequence of thiogalactoside transacetylase of Escherichia coli. Fowler AV, et al. Biochimie, 1985 Jan. PMID 3922433
  5. Purification of thiogalactoside transacetylase by affinity chromatography. Zabin I, et al. Anal Biochem, 1984 Feb. PMID 6372544

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on complete protein
    Title: The amino acid sequence of thiogalactoside transacetylase of Escherichia coli.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables O-acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables galactoside O-acetyltransferase activity EXP
Inferred from Experiment
more info
 PubMed 
enables galactoside O-acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables galactoside O-acetyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables galactoside O-acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm EXP
Inferred from Experiment
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
galactoside O-acetyltransferase
NP_414876.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    361249..361860 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414876.1 galactoside O-acetyltransferase

    See identical proteins and their annotated locations for NP_414876.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C6FW75
    Conserved Domains (1) summary
    PRK09527
    Location:1 → 203
    lacA; galactoside O-acetyltransferase; Reviewed
Nucleotide Protein
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