tmk Tmk [Escherichia coli str. K-12 substr. MG1655] - Gene

Summary

Official Symbol: tmk
Official Full Name: Tmk
Primary source: ECOCYC:EG12302
Locus tag: b1098
See related: ASAP:ABE-0003714
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage: Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as: ECK1084; ycfG
Summary: Essential gene. [More information is available at EcoGene: EG12302]. The enzyme is responsible for specifically catalyzing the conversion of dTMP to dTDP. dTMP kinase is the last unique enzyme in the pathway leading to dTTP. [More information is available at EcoCyc: EG12302].
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NC_000913.3 Genomic Context describing neighboring genes

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Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables dTMP kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables dTMP kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables dTMP kinase activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in dTDP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within dTDP biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in dTDP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in dTDP biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dTTP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within dTTP biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in dTTP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in dTTP biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dUDP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within nucleobase-containing small molecule interconversion	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed