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emtA lytic murein transglycosylase E [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945655, updated on 6-Jul-2026
Official Symbol
emtA
Official Full Name
lytic murein transglycosylase E
Primary source
ECOCYC:G6622
Locus tag
b1193
See related
ASAP:ABE-0004006
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1181; mltE; sltZ; ycgP
Summary
First 15 aa are a type II signal peptide. [More information is available at EcoGene: EG13897]. EmtA is a lytic endotransglycosylase which is expressed in Escherichia coli as a membrane-bound lipoprotein. [More information is available at EcoCyc: G6622].
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Sequence:
NC_000913.3 (1243180..1243791)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene protein YmgM Neighboring gene putative K(+):H(+) antiporter Neighboring gene murein tetrapeptide carboxypeptidase Neighboring gene flagellar brake protein YcgR Neighboring gene PF04226 family protein YmgE

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. A Structural Dissection of the Active Site of the Lytic Transglycosylase MltE from Escherichia coli. Dik DA, et al. Biochemistry, 2018 Oct 23. PMID 30256085
  2. Mechanism of the Escherichia coli MltE lytic transglycosylase, the cell-wall-penetrating enzyme for Type VI secretion system assembly. Byun B, et al. Sci Rep, 2018 Mar 7. PMID 29515200, Free PMC Article
  3. On the mechanism of peptidoglycan binding and cleavage by the endo-specific lytic transglycosylase MltE from Escherichia coli. Fibriansah G, et al. Biochemistry, 2012 Nov 13. PMID 23075328
  4. High-resolution crystal structure of MltE, an outer membrane-anchored endolytic peptidoglycan lytic transglycosylase from Escherichia coli. Artola-Recolons C, et al. Biochemistry, 2011 Apr 5. PMID 21341761, Free PMC Article
  5. Membrane-bound lytic endotransglycosylase in Escherichia coli. Kraft AR, et al. J Bacteriol, 1998 Jul. PMID 9642199, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mechanism of the Escherichia coli MltE lytic transglycosylase, the cell-wall-penetrating enzyme for Type VI secretion system assembly.
    Title: Mechanism of the Escherichia coli MltE lytic transglycosylase, the cell-wall-penetrating enzyme for Type VI secretion system assembly.
  2. A Structural Dissection of the Active Site of the Lytic Transglycosylase MltE from Escherichia coli.
    Title: A Structural Dissection of the Active Site of the Lytic Transglycosylase MltE from Escherichia coli.
  3. results indicate that catalysis of glycosidic bond cleavage by MltE proceeds via distortion toward a sofa-like conformation of the N-acetylmuramic acid sugar ring at subsite -1 and by anchimeric assistance of the sugar's N-acetyl group.
    Title: On the mechanism of peptidoglycan binding and cleavage by the endo-specific lytic transglycosylase MltE from Escherichia coli.
  4. high-resolution (2.0 A) crystal structure of MltE: molecular model; substrate specificity; proposed catalytic mechanism as endolytic enzyme; membrane anchor; comparison with molecular model of Slt70
    Title: High-resolution crystal structure of MltE, an outer membrane-anchored endolytic peptidoglycan lytic transglycosylase from Escherichia coli.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables carbon-oxygen lyase activity, acting on polysaccharides IEA
Inferred from Electronic Annotation
more info
  
enables lytic endotransglycosylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables lytic endotransglycosylase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidoglycan lytic transglycosylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables peptidoglycan lytic transglycosylase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell division EXP
Inferred from Experiment
more info
 PubMed 
involved_in cell wall macromolecule catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in peptidoglycan metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell outer membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cell outer membrane ISM
Inferred from Sequence Model
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
lytic murein transglycosylase E

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1243180..1243791
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415711.2 lytic murein transglycosylase E

    See identical proteins and their annotated locations for NP_415711.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A7ZKW4
    Conserved Domains (1) summary
    PRK15470
    Location:1 → 203
    emtA; membrane-bound lytic murein transglycosylase EmtA
Nucleotide Protein
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