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leuD 3-isopropylmalate dehydratase subunit LeuD [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945642, updated on 9-Mar-2022

Summary

Gene symbol
leuD
Gene description
3-isopropylmalate dehydratase subunit LeuD
Primary source
ASAP:ABE-0000259
Locus tag
b0071
See related
ECOCYC:EG11575
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0073
Summary
Isopropylmalate isomerase catalyzes the second step in leucine biosynthesis, converting 2-isopropylmalate to 3-isopropylmalate. [More information is available at EcoCyc: EG11575].
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Genomic context

Sequence:
NC_000913.3 (78848..79453, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene PtsG glucose transporter inhibitor Neighboring gene sugar exporter SetA Neighboring gene 3-isopropylmalate dehydratase subunit LeuC Neighboring gene 3-isopropylmalate dehydrogenase Neighboring gene 2-isopropylmalate synthase

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables 3-isopropylmalate dehydratase activity IEA
Inferred from Electronic Annotation
more info
 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in branched-chain amino acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular amino acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in leucine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within leucine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of 3-isopropylmalate dehydratase complex IEA
Inferred from Electronic Annotation
more info
 
part_of 3-isopropylmalate dehydratase complex IGI
Inferred from Genetic Interaction
more info
PubMed 
part_of 3-isopropylmalate dehydratase complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
3-isopropylmalate dehydratase subunit LeuD
NP_414613.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    78848..79453 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414613.1 3-isopropylmalate dehydratase subunit LeuD [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414613.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P30126
    Conserved Domains (1) summary
    PRK01641
    Location:3200
    leuD; 3-isopropylmalate dehydratase small subunit