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pgaC poly-N-acetyl-D-glucosamine synthase subunit PgaC [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945606, updated on 23-Apr-2026
Official Symbol
pgaC
Official Full Name
poly-N-acetyl-D-glucosamine synthase subunit PgaC
Primary source
ECOCYC:G6529
Locus tag
b1022
See related
ASAP:ABE-0003464
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1012; hmsR; ycdQ
Summary
PgaC complements a mutation in the homologous Y. pestis hemin storage gene hmsR. [More information is available at EcoGene: EG13863]. The pgaABCD locus is required for the synthesis of a cell-bound hexosamine-rich polysaccharide, which was identified as a linear polymer of beta-1,6-N-acetylglucosamine residues (PGA), an adhesin essential in biofilm formation . [More information is available at EcoCyc: G6529].
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Sequence:
NC_000913.3 (1086521..1087846, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene ATP-binding protein PhoH Neighboring gene poly-N-acetyl-D-glucosamine synthase subunit PgaD Neighboring gene poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase and beta-1,6 glycoside hydrolase Neighboring gene partially deacetylated poly-beta-1,6-N-acetyl-D-glucosamine export outer membrane porin Neighboring gene putative diguanylate cyclase DgcT

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Depolymerization of beta-1,6-N-acetyl-D-glucosamine disrupts the integrity of diverse bacterial biofilms. Itoh Y, et al. J Bacteriol, 2005 Jan. PMID 15601723, Free PMC Article
  2. Allosteric activation of exopolysaccharide synthesis through cyclic di-GMP-stimulated protein-protein interaction. Steiner S, et al. EMBO J, 2013 Feb 6. PMID 23202856, Free PMC Article
  3. HmsT, a protein essential for expression of the haemin storage (Hms+) phenotype of Yersinia pestis. Jones HA, et al. Microbiology (Reading), 1999 Aug. PMID 10463178
  4. Effect of growth conditions on poly-N-acetylglucosamine expression and biofilm formation in Escherichia coli. Cerca N, et al. FEMS Microbiol Lett, 2008 Jun. PMID 18445167
  5. Spatial periodicity of Escherichia coli K-12 biofilm microstructure initiates during a reversible, polar attachment phase of development and requires the polysaccharide adhesin PGA. Agladze K, et al. J Bacteriol, 2005 Dec. PMID 16321928, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. R222 of PgaC plays an essential role in c-di-GMP-dependent PgaCD activation
    Title: Allosteric activation of exopolysaccharide synthesis through cyclic di-GMP-stimulated protein-protein interaction.
  2. Mutants lacking the polysaccharide adhesin beta-1,6-N-acetyl-d-glucosamine (DeltapgaC) also exhibited aperiodic cell distribution, but without apparent cell-cell interactions, and were defective in forming permanent attachments.
    Title: Spatial periodicity of Escherichia coli K-12 biofilm microstructure initiates during a reversible, polar attachment phase of development and requires the polysaccharide adhesin PGA.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables acetylglucosaminyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables acetylglucosaminyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables acetylglucosaminyltransferase activity RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell adhesion involved in biofilm formation EXP
Inferred from Experiment
more info
 PubMed 
involved_in cell adhesion involved in biofilm formation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cell adhesion involved in biofilm formation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell adhesion involved in biofilm formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Preferred Names
poly-N-acetyl-D-glucosamine synthase subunit PgaC

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1086521..1087846 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415541.1 poly-N-acetyl-D-glucosamine synthase subunit PgaC

    See identical proteins and their annotated locations for NP_415541.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A792HM93
    Conserved Domains (1) summary
    PRK11204
    Location:21 → 438
    PRK11204; N-glycosyltransferase; Provisional
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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