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cbpM chaperone modulator CbpM [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945597, updated on 10-Oct-2024

Summary

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Official Symbol
cbpM
Official Full Name
chaperone modulator CbpM
Primary source
ECOCYC:EG12194
Locus tag
b0999
See related
ASAP:ABE-0003377
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0990; yccD
Summary
Purified CbpM protein specifically inhibits both the DNA binding and co-chaperone activity of CbpA . [More information is available at EcoCyc: EG12194].
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Genomic context

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Sequence:
NC_000913.3 (1062550..1062855, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene cytochrome c menaquinol dehydrogenase TorC Neighboring gene trimethylamine N-oxide reductase 1 Neighboring gene trimethylamine-N-oxide reductase-specific chaperone Neighboring gene curved DNA-binding protein Neighboring gene uncharacterized protein YccE

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A conserved acidic amino acid mediates the interaction between modulators and co-chaperones in enterobacteria. Chintakayala K, et al. J Mol Biol, 2011 Aug 12. PMID 21683710
  2. Complex regulation of the DnaJ homolog CbpA by the global regulators sigmaS and Lrp, by the specific inhibitor CbpM, and by the proteolytic degradation of CbpM. Chenoweth MR, et al. J Bacteriol, 2008 Aug. PMID 18502857, Free PMC Article
  3. Functional analysis of CbpA, a DnaJ homolog and nucleoid-associated DNA-binding protein. Bird JG, et al. J Biol Chem, 2006 Nov 10. PMID 16973605
  4. An analogue of the DnaJ molecular chaperone whose expression is controlled by sigma s during the stationary phase and phosphate starvation in Escherichia coli. Yamashino T, et al. Mol Microbiol, 1994 Aug. PMID 7997164
  5. An analogue of the DnaJ molecular chaperone in Escherichia coli. Ueguchi C, et al. Proc Natl Acad Sci U S A, 1994 Feb 1. PMID 8302830, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The activity of CbpA is regulated by the "modulator" protein CbpM.
    Title: A conserved acidic amino acid mediates the interaction between modulators and co-chaperones in enterobacteria.
  2. When not bound to CbpA, CbpM was unstable and was degraded by the Lon and ClpAP proteases.
    Title: Complex regulation of the DnaJ homolog CbpA by the global regulators sigmaS and Lrp, by the specific inhibitor CbpM, and by the proteolytic degradation of CbpM.
  3. We discovered that CbpM specifically inhibits the in vivo activity of CbpA, preventing it from functioning in cell growth and division.
    Title: In vivo modulation of a DnaJ homolog, CbpA, by CbpM.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables enzyme inhibitor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
chaperone modulator CbpM

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1062550..1062855 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415519.1 chaperone modulator CbpM [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415519.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A829L0K3, A0AAN3UZ95, A0AAN4HWH4
    Conserved Domains (1) summary
    PRK10265
    Location:1 → 101
    PRK10265; chaperone modulator CbpM
Nucleotide Protein
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