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pgaA partially deacetylated poly-beta-1,6-N-acetyl-D-glucosamine export outer membrane porin [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945596, updated on 19-Nov-2025
Official Symbol
pgaA
Official Full Name
partially deacetylated poly-beta-1,6-N-acetyl-D-glucosamine export outer membrane porin
Primary source
ECOCYC:G6531
Locus tag
b1024
See related
ASAP:ABE-0003469
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1014; hmsH; ycdS
Summary
PgaA is homolgous to Y. pestis hemin storage protein HmsH, but is unable to complement hmsH mutations. [More information is available at EcoGene: EG13865]. The pgaABCD locus is required for the synthesis of a cell-bound hexosamine-rich polysaccharide, which was identified as a linear polymer of beta-1,6-N-acetylglucosamine residues (PGA), an adhesin essential in biofilm formation . [More information is available at EcoCyc: G6531].
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Sequence:
NC_000913.3 (1089866..1092289, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene poly-N-acetyl-D-glucosamine synthase subunit PgaD Neighboring gene poly-N-acetyl-D-glucosamine synthase subunit PgaC Neighboring gene poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase and beta-1,6 glycoside hydrolase Neighboring gene putative diguanylate cyclase DgcT Neighboring gene IS3 element protein InsF Neighboring gene IS3 element protein InsE

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Depolymerization of beta-1,6-N-acetyl-D-glucosamine disrupts the integrity of diverse bacterial biofilms. Itoh Y, et al. J Bacteriol, 2005 Jan. PMID 15601723, Free PMC Article
  2. HmsT, a protein essential for expression of the haemin storage (Hms+) phenotype of Yersinia pestis. Jones HA, et al. Microbiology (Reading), 1999 Aug. PMID 10463178
  3. Effect of growth conditions on poly-N-acetylglucosamine expression and biofilm formation in Escherichia coli. Cerca N, et al. FEMS Microbiol Lett, 2008 Jun. PMID 18445167
  4. Spatial periodicity of Escherichia coli K-12 biofilm microstructure initiates during a reversible, polar attachment phase of development and requires the polysaccharide adhesin PGA. Agladze K, et al. J Bacteriol, 2005 Dec. PMID 16321928, Free PMC Article
  5. Second messenger signalling governs Escherichia coli biofilm induction upon ribosomal stress. Boehm A, et al. Mol Microbiol, 2009 Jun. PMID 19460094

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables poly-beta-1,6-N-acetyl-D-glucosamine transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables polysaccharide transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables polysaccharide transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within polysaccharide transport IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within polysaccharide transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within single-species biofilm formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell outer membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
partially deacetylated poly-beta-1,6-N-acetyl-D-glucosamine export outer membrane porin

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1089866..1092289 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415543.1 partially deacetylated poly-beta-1,6-N-acetyl-D-glucosamine export outer membrane porin

    See identical proteins and their annotated locations for NP_415543.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A2W6PYQ1
    Conserved Domains (2) summary
    PRK10049
    Location:53 → 807
    pgaA; outer membrane protein PgaA; Provisional
    sd00006
    Location:98 → 126
    TPR; TPR repeat [structural motif]
Nucleotide Protein
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