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dgcT putative diguanylate cyclase DgcT [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945593, updated on 23-Apr-2026
Official Symbol
dgcT
Official Full Name
putative diguanylate cyclase DgcT
Primary source
ECOCYC:G6532
Locus tag
b1025
See related
ASAP:ABE-0003472
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1015; ycdT
Summary
YcdT mRNA is translationally repressed by CsrA (Jonas, 2008). ycdT overexpression causes a 20-fold increase in di-c-GMP and represses motility, but a mutant has little effect (Jonas, 2008). [More information is available at EcoGene: EG13866]. YcdT is a diguanylate cyclase that regulates motility; the effect on motility is probably mediated by the second messenger c-di-GMP . [More information is available at EcoCyc: G6532].
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Sequence:
NC_000913.3 (1092876..1094234)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene poly-N-acetyl-D-glucosamine synthase subunit PgaC Neighboring gene poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase and beta-1,6 glycoside hydrolase Neighboring gene partially deacetylated poly-beta-1,6-N-acetyl-D-glucosamine export outer membrane porin Neighboring gene IS3 element protein InsF Neighboring gene IS3 element protein InsE Neighboring gene pseudo Neighboring gene uncharacterized protein YcdU

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. The diguanylate cyclase YddV controls production of the exopolysaccharide poly-N-acetylglucosamine (PNAG) through regulation of the PNAG biosynthetic pgaABCD operon. Tagliabue L, et al. Microbiology (Reading), 2010 Oct. PMID 20576684
  2. Allosteric activation of exopolysaccharide synthesis through cyclic di-GMP-stimulated protein-protein interaction. Steiner S, et al. EMBO J, 2013 Feb 6. PMID 23202856, Free PMC Article
  3. HmsT, a protein essential for expression of the haemin storage (Hms+) phenotype of Yersinia pestis. Jones HA, et al. Microbiology (Reading), 1999 Aug. PMID 10463178
  4. The RNA binding protein CsrA controls cyclic di-GMP metabolism by directly regulating the expression of GGDEF proteins. Jonas K, et al. Mol Microbiol, 2008 Oct. PMID 18713317, Free PMC Article
  5. Gene expression patterns and differential input into curli fimbriae regulation of all GGDEF/EAL domain proteins in Escherichia coli. Sommerfeldt N, et al. Microbiology (Reading), 2009 Apr. PMID 19332833

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables diguanylate cyclase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables diguanylate cyclase activity IEA
Inferred from Electronic Annotation
more info
  
enables diguanylate cyclase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in c-di-GMP signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within single-species submerged biofilm formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
putative diguanylate cyclase DgcT
NP_415544.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1092876..1094234
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415544.1 putative diguanylate cyclase DgcT

    See identical proteins and their annotated locations for NP_415544.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A8T6BJW7
    Conserved Domains (2) summary
    pfam00990
    Location:282 → 439
    GGDEF; Diguanylate cyclase, GGDEF domain
    pfam17158
    Location:43 → 275
    MASE4; Membrane-associated sensor, integral membrane domain
Nucleotide Protein
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