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appC cytochrome bd-II subunit 1 [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945585, updated on 19-Nov-2025
Official Symbol
appC
Official Full Name
cytochrome bd-II subunit 1
Primary source
ECOCYC:EG11380
Locus tag
b0978
See related
ASAP:ABE-0003300
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
cbdA; cyxA; ECK0969
Summary
EvgAS regulon. [More information is available at EcoGene: EG11380].
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Sequence:
NC_000913.3 (1037740..1039284)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene hydrogenase 1 cytochrome b subunit Neighboring gene putative hydrogenase 1 maturation protease HyaD Neighboring gene putative HyaA chaperone Neighboring gene protein HyaF Neighboring gene cytochrome bd-II subunit 2 Neighboring gene cytochrome bd-II accessory subunit AppX

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Preparations of Terminal Oxidase Cytochrome bd-II Isolated from Escherichia coli Reveal Significant Hydrogen Peroxide Scavenging Activity. Forte E, et al. Biochemistry (Mosc), 2022 Aug. PMID 36171653
  2. Aerobic respiratory chain of Escherichia coli is not allowed to work in fully uncoupled mode. Borisov VB, et al. Proc Natl Acad Sci U S A, 2011 Oct 18. PMID 21987791, Free PMC Article
  3. Cytochrome bd oxidase and nitric oxide: from reaction mechanisms to bacterial physiology. Giuffrè A, et al. FEBS Lett, 2012 Mar 9. PMID 21821033
  4. Respiration of Escherichia coli can be fully uncoupled via the nonelectrogenic terminal cytochrome bd-II oxidase. Bekker M, et al. J Bacteriol, 2009 Sep. PMID 19542282, Free PMC Article
  5. Aerobic fermentation of D-glucose by an evolved cytochrome oxidase-deficient Escherichia coli strain. Portnoy VA, et al. Appl Environ Microbiol, 2008 Dec. PMID 18952873, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Preparations of Terminal Oxidase Cytochrome bd-II Isolated from Escherichia coli Reveal Significant Hydrogen Peroxide Scavenging Activity.
    Title: Preparations of Terminal Oxidase Cytochrome bd-II Isolated from Escherichia coli Reveal Significant Hydrogen Peroxide Scavenging Activity.
  2. Studies suggest that the prokaryotic respiratory cytochrome bd quinol oxidase is responsible for both bioenergetic functions and bacterial adaptation to different stress conditions.
    Title: Cytochrome bd oxidase and nitric oxide: from reaction mechanisms to bacterial physiology.
  3. Proposed arrangement of transmembrane helices in subunit I of cytochrome bd quinol oxidase may explain possible roles of conserved hydrophilic residues within the membrane.
    Title: Glutamates 99 and 107 in transmembrane helix III of subunit I of cytochrome bd are critical for binding of the heme b595-d binuclear center and enzyme activity.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables cytochrome bo3 ubiquinol oxidase activity IEA
Inferred from Electronic Annotation
more info
  
enables electron transfer activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables electron transfer activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables electron transfer activity IEA
Inferred from Electronic Annotation
more info
  
enables heme binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables heme binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in aerobic electron transport chain IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within aerobic electron transport chain IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in aerobic electron transport chain IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within aerobic electron transport chain IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in oxidative phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of cytochrome complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytochrome complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cytochrome complex IEA
Inferred from Electronic Annotation
more info
  
located_in membrane HDA PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISM
Inferred from Sequence Model
more info
 PubMed 
Preferred Names
cytochrome bd-II subunit 1
NP_415497.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1037740..1039284
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415497.1 cytochrome bd-II subunit 1

    See identical proteins and their annotated locations for NP_415497.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1X3JKM6
    Conserved Domains (1) summary
    PRK15035
    Location:1 → 514
    PRK15035; cytochrome bd-II oxidase subunit 1; Provisional
Nucleotide Protein
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