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hyaC hydrogenase 1 cytochrome b subunit [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945581, updated on 4-Feb-2026
Official Symbol
hyaC
Official Full Name
hydrogenase 1 cytochrome b subunit
Primary source
ECOCYC:EG10470
Locus tag
b0974
See related
ASAP:ABE-0003290
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
cybH; ECK0965
Summary
The hyaC gene product is very hydrophobic, rich in aromatic residues, and has four putative hydrophobic membrane-spanning regions . [More information is available at EcoCyc: EG10470].
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Sequence:
NC_000913.3 (1035066..1035773)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene tRNA-Ser Neighboring gene hydrogenase 1 small subunit Neighboring gene hydrogenase 1 large subunit Neighboring gene putative hydrogenase 1 maturation protease HyaD Neighboring gene putative HyaA chaperone Neighboring gene protein HyaF Neighboring gene cytochrome bd-II subunit 1

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Crystal structure of dimeric membrane-bound O(2)-tolerant hydrogenase 1 from Escherichia coli in a 2:1 complex with its physiological partner, cytochrome b.
    Title: Crystal structure of the O(2)-tolerant membrane-bound hydrogenase 1 from Escherichia coli in complex with its cognate cytochrome b.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables electron transfer activity IEA
Inferred from Electronic Annotation
more info
  
enables heme binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables heme binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables hydrogenase (acceptor) activity IC
Inferred by Curator
more info
 PubMed 
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within anaerobic electron transport chain IC
Inferred by Curator
more info
 PubMed 
involved_in anaerobic electron transport chain IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in anaerobic respiration IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within anaerobic respiration IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cellular response to starvation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within hydrogen metabolic process IC
Inferred by Curator
more info
 PubMed 
involved_in respiratory electron transport chain IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of [Ni-Fe] hydrogenase complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in periplasmic side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISM
Inferred from Sequence Model
more info
 PubMed 
Preferred Names
hydrogenase 1 cytochrome b subunit
NP_415493.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1035066..1035773
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415493.1 hydrogenase 1 cytochrome b subunit

    See identical proteins and their annotated locations for NP_415493.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A377DU59
    Conserved Domains (1) summary
    PRK10171
    Location:1 → 235
    PRK10171; Ni/Fe-hydrogenase b-type cytochrome subunit
Nucleotide Protein
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