U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

rmf [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945567, updated on 11-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
rmf
Primary source
ECOCYC:EG50004
Locus tag
b0953
See related
ASAP:ABE-0003227
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0944; res; rimF
Summary
Rmf is a ribosome modulation factor that reversibly converts active 70S ribosomes to a dimeric form (100S ribosomes), which appears during the transition from exponential growth to stationary phase and is associated with a decrease in overall translation activity . [More information is available at EcoCyc: EG50004].
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Sequence:
NC_000913.3 (1015715..1015882)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene intermembrane transport protein PqiA Neighboring gene intermembrane transport protein PqiB Neighboring gene intermembrane transport lipoprotein PqiC Neighboring gene beta-hydroxyacyl-acyl carrier protein dehydratase/isomerase Neighboring gene putative ATP-dependent protease YcbZ

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The influence of ribosome modulation factor on the survival of stationary-phase Escherichia coli during acid stress. El-Sharoud WM, et al. Microbiology (Reading), 2007 Jan. PMID 17185553
  2. Improved production of enzymes, which are expressed under the Pho regulon promoter, in the rmf gene (encoding ribosome modulation factor) disruptant of Escherichia coli. Imaizumi A, et al. Biosci Biotechnol Biochem, 2006 Apr. PMID 16636463
  3. The activity of ribosome modulation factor during growth of Escherichia coli under acidic conditions. el-Sharoud WM, et al. Arch Microbiol, 2005 Oct. PMID 16088400
  4. Improved production of L-lysine by disruption of stationary phase-specific rmf gene in Escherichia coli. Imaizumi A, et al. J Biotechnol, 2005 Apr 20. PMID 15831252
  5. Modulation of mRNA stability participates in stationary-phase-specific expression of ribosome modulation factor. Aiso T, et al. J Bacteriol, 2005 Mar. PMID 15743942, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data propose that CRP regulates transcription activation of the rmf gene for formation of 100S ribosome dimers.
    Title: Involvement of cyclic AMP receptor protein in regulation of the rmf gene encoding the ribosome modulation factor in Escherichia coli.
  2. crystal structure of Thermus thermophilus 70S ribosome in complex with stationary-phase factors RMF, HPF and YfiA; binding site of RMF overlaps with that of mRNA Shine-Dalgarno sequence, which prevents interaction between the mRNA and the 16S ribosomal RNA
    Title: How hibernation factors RMF, HPF, and YfiA turn off protein synthesis.
  3. Data showed that FtsY depletion inhibits the translation of both SRP-dependent and independent proteins. This synthesis defect is the result of a multifaceted response that includes the upregulation of the ribosome-inactivating protein RMF.
    Title: Depletion of the signal recognition particle receptor inactivates ribosomes in Escherichia coli.
  4. Ribosomes change into forms which are hard to bind with IF3 and easy to form 100S ribosomes by RMF and HPF concomitantly with transition from the log phase to the stationary phase.
    Title: Activities of Escherichia coli ribosomes in IF3 and RMF change to prepare 100S ribosome formation on entering the stationary growth phase.
  5. N-terminus verified by Edman degradation on complete protein
    Title: Structure and probable genetic location of a "ribosome modulation factor" associated with 100S ribosomes in stationary-phase Escherichia coli cells.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables rRNA binding IEA
Inferred from Electronic Annotation
more info
  
enables ribosomal small subunit binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ribosome binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in dormancy process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in dormancy process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of translation in response to stress IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
ribosome modulation factor

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1015715..1015882
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415473.1 ribosome modulation factor [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415473.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A5B9AK61
    Conserved Domains (1) summary
    PRK14563
    Location:1 → 55
    PRK14563; ribosome modulation factor; Provisional
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.