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kdsB 3-deoxy-manno-octulosonate cytidylyltransferase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945539, updated on 25-Jun-2025
Official Symbol
kdsB
Official Full Name
3-deoxy-manno-octulosonate cytidylyltransferase
Primary source
ECOCYC:EG10519
Locus tag
b0918
See related
ASAP:ABE-0003122
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0909
Summary
CMP-KDO synthetase activates the 8-carbon sugar KDO for incorporation into lipopolysaccharide. [More information is available at EcoCyc: EG10519].
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Sequence:
NC_000913.3 (970852..971598)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene ATP-binding lipopolysaccharide transport protein Neighboring gene tetraacyldisaccharide 4'-kinase Neighboring gene interstrand DNA crosslink repair glycosylase Neighboring gene PF03966 family protein YcaR Neighboring gene putative phosphotransferase YcbJ Neighboring gene envelope biogenesis factor Neighboring gene tRNA cmo(5)U34 methyltransferase Neighboring gene chromosome partitioning protein MukF

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Structure-based mechanism of CMP-2-keto-3-deoxymanno-octulonic acid synthetase: convergent evolution of a sugar-activating enzyme with DNA/RNA polymerases. Heyes DJ, et al. J Biol Chem, 2009 Dec 18. PMID 19815542, Free PMC Article
  2. An Escherichia coli expression vector for high-level production of heterologous proteins in fusion with CMP-KDO synthetase. Bolling TJ, et al. Biotechniques, 1990 May. PMID 2162683
  3. Molecular cloning of the structural gene coding for CTP:CMP-3-deoxy-manno-octulosonate cytidylyltransferase from Escherichia coli K-12. Goldman RC, et al. J Bacteriol, 1985 Jul. PMID 2989246, Free PMC Article
  4. Determination of the anomeric specificity of the Escherichia coli CTP:CMP-3-deoxy-D-manno-octulosonate cytidylyltransferase by 13C NMR spectroscopy. Kohlbrenner WE, et al. J Biol Chem, 1985 Nov 25. PMID 2997221
  5. 31P and 13C NMR studies of oxygen transfer during catalysis by 3-deoxy-D-manno-octulosonate cytidylyltransferase from Escherichia coli. Kohlbrenner WE, et al. J Biol Chem, 1987 Apr 5. PMID 3031027

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on mature peptide
    Title: Primary structure of CTP:CMP-3-deoxy-D-manno-octulosonate cytidylyltransferase (CMP-KDO synthetase) from Escherichia coli.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 3-deoxy-manno-octulosonate cytidylyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3-deoxy-manno-octulosonate cytidylyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in keto-3-deoxy-D-manno-octulosonic acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within keto-3-deoxy-D-manno-octulosonic acid biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
3-deoxy-manno-octulosonate cytidylyltransferase
NP_415438.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    970852..971598
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415438.1 3-deoxy-manno-octulosonate cytidylyltransferase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415438.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A2X1JGJ5, A0A376X0Q8
    Conserved Domains (1) summary
    PRK05450
    Location:1 → 248
    PRK05450; 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional
Nucleotide Protein
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