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radD putative DNA repair helicase RadD [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945529, updated on 10-Oct-2024

Summary

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Official Symbol
radD
Official Full Name
putative DNA repair helicase RadD
Primary source
ECOCYC:EG12045
Locus tag
b2184
See related
ASAP:ABE-0007228
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2178; yejH; yejI; yejJ
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Genomic context

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Sequence:
NC_000913.3 (2280632..2282392)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene multidrug efflux pump Bcr Neighboring gene 16S rRNA pseudouridine(516) synthase Neighboring gene 50S ribosomal subunit protein L25 Neighboring gene nucleoid-associated protein YejK

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Interaction with single-stranded DNA-binding protein modulates Escherichia coli RadD DNA repair activities. Osorio Garcia MA, et al. J Biol Chem, 2023 Jun. PMID 37142225, Free PMC Article
  2. Biochemical and Structural Analyses Shed Light on the Mechanisms of RadD DNA Binding and Its ATPase from Escherichia coli. Tian LF, et al. Int J Mol Sci, 2023 Jan 1. PMID 36614183, Free PMC Article
  3. Crystal structure of a novel ATPase RadD from Escherichia coli. Kuang X, et al. Proteins, 2019 Sep. PMID 31035307
  4. Escherichia coli radD (yejH) gene: a novel function involved in radiation resistance and double-strand break repair. Chen SH, et al. Mol Microbiol, 2015 Mar. PMID 25425430, Free PMC Article
  5. Frequent template switching in postreplication gaps: suppression of deleterious consequences by the Escherichia coli Uup and RadD proteins. Romero ZJ, et al. Nucleic Acids Res, 2020 Jan 10. PMID 31665437, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Interaction with single-stranded DNA-binding protein modulates Escherichia coli RadD DNA repair activities.
    Title: Interaction with single-stranded DNA-binding protein modulates Escherichia coli RadD DNA repair activities.
  2. Biochemical and Structural Analyses Shed Light on the Mechanisms of RadD DNA Binding and Its ATPase from Escherichia coli.
    Title: Biochemical and Structural Analyses Shed Light on the Mechanisms of RadD DNA Binding and Its ATPase from Escherichia coli.
  3. Resolving Toxic DNA repair intermediates in every E. coli replication cycle: critical roles for RecG, Uup and RadD.
    Title: Resolving Toxic DNA repair intermediates in every E. coli replication cycle: critical roles for RecG, Uup and RadD.
  4. RadD protein suppresses crossovers, and Uup prevents nucleoid mis-segregation during Dna replication of defective DNA sequences.
    Title: Frequent template switching in postreplication gaps: suppression of deleterious consequences by the Escherichia coli Uup and RadD proteins.
  5. it is likely that the repair function of RadD is mediated through interaction with SSB at the site of damage.
    Title: Escherichia coli RadD Protein Functionally Interacts with the Single-stranded DNA-binding Protein.
  6. investigation of the function of yejH; established a role for yejH gene product in repair of double-strand breaks that largely overlaps that of the genes radA and recG; propose yejH be renamed radD, reflecting its role in DNA repair of radiation damage
    Title: Escherichia coli radD (yejH) gene: a novel function involved in radiation resistance and double-strand break repair.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP hydrolysis activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables single-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within double-strand break repair EXP
Inferred from Experiment
more info
 PubMed 
acts_upstream_of_or_within double-strand break repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within postreplication repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to ionizing radiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to xenobiotic stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in translation IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
putative DNA repair helicase RadD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2280632..2282392
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416689.1 putative DNA repair helicase RadD [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416689.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A2X1QM92, A0AAN5J9X5
    Conserved Domains (2) summary
    COG1061
    Location:1 → 364
    SSL2; Superfamily II DNA or RNA helicase [Transcription, Replication, recombination and repair]
    cl00671
    Location:428 → 451
    Ribosomal_L40e; Ribosomal L40e family
Nucleotide Protein
Heading Accession and Version

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