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acrR DNA-binding transcriptional repressor AcrR [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945516, updated on 19-Feb-2025

Summary

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Official Symbol
acrR
Official Full Name
DNA-binding transcriptional repressor AcrR
Primary source
ECOCYC:EG12116
Locus tag
b0464
See related
ASAP:ABE-0001608
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0458; ybaH
Summary
TetR family. [More information is available at EcoGene: EG12116]. The "acriflavine resistance regulator", AcrR, regulates the expression of genes involved in multidrug transport and is classified in the nodulation-resistance division family . [More information is available at EcoCyc: EG12116].
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Genomic context

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Sequence:
NC_000913.3 (485761..486408)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene multidrug efflux pump RND permease AcrB Neighboring gene multidrug efflux pump membrane fusion lipoprotein AcrA Neighboring gene potassium dependent, small conductance mechanosensitive channel Neighboring gene DUF2496 domain-containing protein YbaM

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic characterization of phenicol-resistant Escherichia coli and role of wild-type repressor/regulator gene (acrR) on phenicol resistance. Yaqoob M, et al. Folia Microbiol (Praha), 2018 Jul. PMID 29307119
  2. Potential Swimming Motility Variation by AcrR in Escherichia coli. Kim YJ, et al. J Microbiol Biotechnol, 2016 Oct 28. PMID 27558437
  3. Structures of AcrR and CmeR: insight into the mechanisms of transcriptional repression and multi-drug recognition in the TetR family of regulators. Routh MD, et al. Biochim Biophys Acta, 2009 May. PMID 19130905, Free PMC Article
  4. Conformational change of the AcrR regulator reveals a possible mechanism of induction. Gu R, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2008 Jul 1. PMID 18607081, Free PMC Article
  5. Characterization of the multidrug efflux regulator AcrR from Escherichia coli. Su CC, et al. Biochem Biophys Res Commun, 2007 Sep 14. PMID 17644067, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mutations in AcrR and RNA Polymerase Confer High-Level Resistance to Psoralen-UVA Irradiation.
    Title: Mutations in AcrR and RNA Polymerase Confer High-Level Resistance to Psoralen-UVA Irradiation.
  2. Mutations of AcrR protein in chloramphenicol resistant Ecoli, isolated from diseased chickens, cause the overexpression of AcrA protein of the AcrAB multidrug efflux pump. Complementation with a plasmid-borne wild-type acrR gene reduces the expression level of AcrA protein in the mutants and partially restored antibiotic susceptibility.
    Title: Genetic characterization of phenicol-resistant Escherichia coli and role of wild-type repressor/regulator gene (acrR) on phenicol resistance.
  3. Studied the genome-wide target genes of E. coli AcrR in a DeltaacrR mutant strain by microarray analysis. Motility assays revealed that AcrR modulates swimming motility, but not swarming.
    Title: Potential Swimming Motility Variation by AcrR in Escherichia coli.
  4. PCR analysis of RNA from the wild-type, DeltaacrR, and acrR (+) strains showed that AcrR represses the transcription of marRAB and soxRS, and its own gene cluster, acrRAB.
    Title: Overproduction of AcrR increases organic solvent tolerance mediated by modulation of SoxS regulon in Escherichia coli.
  5. A palindrome operator sequence that binds the multidrug efflux regulator AcrR was determined.
    Title: Characterization of the multidrug efflux regulator AcrR from Escherichia coli.
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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables toxic substance binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription cis-regulatory region binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription cis-regulatory region binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within response to xenobiotic stimulus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
DNA-binding transcriptional repressor AcrR

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    485761..486408
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414997.1 DNA-binding transcriptional repressor AcrR [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414997.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8S7JY64
    Conserved Domains (1) summary
    PRK10668
    Location:1 → 215
    PRK10668; DNA-binding transcriptional repressor AcrR; Provisional
Nucleotide Protein
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