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entC [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945511, updated on 11-Sep-2024

Summary

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Official Symbol
entC
Primary source
ECOCYC:EG10261
Locus tag
b0593
See related
ASAP:ABE-0002047
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0586; fepF
Summary
There are two isochorismate synthase enzymes present in Escherichia coli, encoded by entC and menF. [More information is available at EcoCyc: EG10261].
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Genomic context

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Sequence:
NC_000913.3 (624885..626060)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene enterobactin exporter EntS Neighboring gene ferric enterobactin ABC transporter periplasmic binding protein Neighboring gene 2,3-dihydroxybenzoate-AMP ligase Neighboring gene enterobactin synthase component B Neighboring gene 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Crystal structure of Escherichia coli enterobactin-specific isochorismate synthase (EntC) bound to its reaction product isochorismate: implications for the enzyme mechanism and differential activity of chorismate-utilizing enzymes. Sridharan S, et al. J Mol Biol, 2010 Mar 19. PMID 20079748
  2. Effects of macromolecular crowding on the intrinsic catalytic efficiency and structure of enterobactin-specific isochorismate synthase. Jiang M, et al. J Am Chem Soc, 2007 Jan 31. PMID 17243787
  3. The in vitro conversion of chorismate to isochorismate catalyzed by the Escherichia coli entC gene product. Evidence that EntA does not contribute to isochorismate synthase activity. Tummuru MK, et al. J Biol Chem, 1989 Dec 5. PMID 2684979
  4. Role of the entC gene in enterobactin and menaquinone biosynthesis in Escherichia coli. Kaiser A, et al. Arch Biochem Biophys, 1990 Feb 1. PMID 2154945
  5. Overexpression, purification, and characterization of isochorismate synthase (EntC), the first enzyme involved in the biosynthesis of enterobactin from chorismate. Liu J, et al. Biochemistry, 1990 Feb 13. PMID 2139795

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on complete protein
    Title: Nucleotide sequence of a cluster of Escherichia coli enterobactin biosynthesis genes: identification of entA and purification of its product 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase.
  2. Intrinsic catalytic efficiency and structure of entC was studied.
    Title: Effects of macromolecular crowding on the intrinsic catalytic efficiency and structure of enterobactin-specific isochorismate synthase.
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General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables isochorismate synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables isochorismate synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in enterobactin biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within enterobactin biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
isochorismate synthase EntC
NP_415125.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    624885..626060
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415125.1 isochorismate synthase EntC [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415125.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A2H4TPD2, A0A418GP33, A0A478L4Y9, A0A7A6WKR2
    Conserved Domains (1) summary
    PRK15016
    Location:1 → 391
    PRK15016; isochorismate synthase EntC; Provisional
Nucleotide Protein
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