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cydC glutathione/L-cysteine ABC exporter subunit CydC [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945504, updated on 19-Sep-2024

Summary

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Official Symbol
cydC
Official Full Name
glutathione/L-cysteine ABC exporter subunit CydC
Primary source
ECOCYC:EG10012
Locus tag
b0886
See related
ASAP:ABE-0003012
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0877; mdrA; mdrH; surB; ycaB
Summary
The cydDC operon encodes two ATP-binding cassette (ABC) transporter proteins that are most closely similar to ABC transporters involved in export . [More information is available at EcoCyc: EG10012].
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Genomic context

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Sequence:
NC_000913.3 (927474..929195, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene translation initiation factor IF-1 Neighboring gene leucyl/phenylalanyl-tRNA--protein transferase Neighboring gene glutathione/L-cysteine ABC exporter subunit CydD Neighboring gene thioredoxin reductase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Escherichia coli K-12 on the internet. Rudd KE. Trends Genet, 1996 Apr. PMID 8901421
  2. The stationary-phase-exit defect of cydC (surB) mutants is due to the lack of a functional terminal cytochrome oxidase. Siegele DA, et al. J Bacteriol, 1996 Nov. PMID 8892804, Free PMC Article
  3. CydDC-mediated reductant export in Escherichia coli controls the transcriptional wiring of energy metabolism and combats nitrosative stress. Holyoake LV, et al. Biochem J, 2016 Mar 15. PMID 26699904, Free PMC Article
  4. The CydDC ABC transporter of Escherichia coli: new roles for a reductant efflux pump. Shepherd M. Biochem Soc Trans, 2015 Oct. PMID 26517902
  5. The CydDC Family of Transporters and Their Roles in Oxidase Assembly and Homeostasis. Holyoake LV, et al. Adv Microb Physiol, 2015. PMID 26210105

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ABC-type heme transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ABC-type transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATPase-coupled transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in amino acid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in cell redox homeostasis IEA
Inferred from Electronic Annotation
more info
  
involved_in cell redox homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell redox homeostasis NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in cysteine export across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cysteine export across plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cysteine export across plasma membrane NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in cytochrome biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in glutathione transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in glutathione transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in glutathione transmembrane transport NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in heme transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of ATP-binding cassette (ABC) transporter complex NAS
Non-traceable Author Statement
more info
 PubMed 
part_of ATP-binding cassette (ABC) transporter complex, integrated substrate binding IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
glutathione/L-cysteine ABC exporter subunit CydC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    927474..929195 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415406.1 glutathione/L-cysteine ABC exporter subunit CydC [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415406.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A6M9WS44
    Conserved Domains (1) summary
    PRK11160
    Location:1 → 573
    PRK11160; cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed
Nucleotide Protein
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