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infA [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945500, updated on 24-Aug-2024

Summary

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Official Symbol
infA
Primary source
ECOCYC:EG10504
Locus tag
b0884
See related
ASAP:ABE-0003005
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
bypA1; ECK0875
Summary
INfA acts as transcription antiterminator and has RNA chaperone activity in vivo and in vitro (Phadtare, 2007). [More information is available at EcoGene: EG10504]. IF-1 is one of three translation initiation factors in Escherichia coli and is essential for viability . [More information is available at EcoCyc: EG10504].
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Genomic context

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Sequence:
NC_000913.3 (926225..926443, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene ATP-dependent Clp protease ATP-binding subunit ClpA Neighboring gene tRNA-Ser Neighboring gene leucyl/phenylalanyl-tRNA--protein transferase Neighboring gene glutathione/L-cysteine ABC exporter subunit CydC

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cold-shock-induced de novo transcription and translation of infA and role of IF1 during cold adaptation. Giangrossi M, et al. Mol Microbiol, 2007 May. PMID 17462025
  2. Transcription antitermination by translation initiation factor IF1. Phadtare S, et al. J Bacteriol, 2007 Jun. PMID 17384193, Free PMC Article
  3. Differential promoter usage of infA in response to cold shock in Escherichia coli. Ko JH, et al. FEBS Lett, 2006 Jan 23. PMID 16405963
  4. In vivo involvement of mutated initiation factor IF1 in gene expression control at the translational level. Croitoru VV, et al. FEBS Lett, 2005 Feb 14. PMID 15710381
  5. A host/plasmid system that is not dependent on antibiotics and antibiotic resistance genes for stable plasmid maintenance in Escherichia coli. Hägg P, et al. J Biotechnol, 2004 Jul 1. PMID 15196766

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables rRNA binding IEA
Inferred from Electronic Annotation
more info
  
enables ribosome binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ribosome binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ribosome binding IEA
Inferred from Electronic Annotation
more info
  
enables translation initiation factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
involved_in translational initiation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
translation initiation factor IF-1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    926225..926443 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415404.1 translation initiation factor IF-1 [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415404.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P69222
    Conserved Domains (1) summary
    PRK00276
    Location:1 → 72
    infA; translation initiation factor IF-1; Validated
Nucleotide Protein
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