Format

Send to:

Choose Destination

HOMER2 homer scaffold protein 2 [ Homo sapiens (human) ]

Gene ID: 9455, updated on 13-Feb-2019

Summary

Official Symbol
HOMER2provided by HGNC
Official Full Name
homer scaffold protein 2provided by HGNC
Primary source
HGNC:HGNC:17513
See related
Ensembl:ENSG00000103942 MIM:604799
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CPD; ACPD; DFNA68; VESL-2; HOMER-2
Summary
This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function. The encoded protein is a postsynaptic density scaffolding protein. Alternative splicing results in multiple transcript variants. Two related pseudogenes have been identified on chromosome 14. [provided by RefSeq, Jun 2011]
Expression
Broad expression in prostate (RPKM 9.3), pancreas (RPKM 6.8) and 16 other tissues See more
Orthologs

Genomic context

See HOMER2 in Genome Data Viewer
Location:
15q25.2
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 15 NC_000015.10 (82836946..82986176, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (83517729..83654905, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene small Cajal body-specific RNA 15 Neighboring gene small nucleolar RNA host gene 21 Neighboring gene fibronectin type III and SPRY domain containing 2 Neighboring gene WASP homolog associated with actin, golgi membranes and microtubules Neighboring gene uncharacterized LOC105370928 Neighboring gene chromosome 15 open reading frame 40 Neighboring gene RNA guanine-7 methyltransferase activating subunit Neighboring gene BTB domain containing 1 Neighboring gene fatty acid binding protein 5 pseudogene 8

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • FoxO signaling pathway, organism-specific biosystem (from KEGG)
    FoxO signaling pathway, organism-specific biosystemThe forkhead box O (FOXO) family of transcription factors regulates the expression of genes in cellular physiological events including apoptosis, cell-cycle control, glucose metabolism, oxidative str...
  • Glutamatergic synapse, organism-specific biosystem (from KEGG)
    Glutamatergic synapse, organism-specific biosystemGlutamate is the major excitatory neurotransmitter in the mammalian central nervous system(CNS). Glutamate is packaged into synaptic vesicles in the presynaptic terminal. Once released into the synap...
  • Glutamatergic synapse, conserved biosystem (from KEGG)
    Glutamatergic synapse, conserved biosystemGlutamate is the major excitatory neurotransmitter in the mammalian central nervous system(CNS). Glutamate is packaged into synaptic vesicles in the presynaptic terminal. Once released into the synap...
  • Interactions of neurexins and neuroligins at synapses, organism-specific biosystem (from REACTOME)
    Interactions of neurexins and neuroligins at synapses, organism-specific biosystemNeurexins (NRXNs) and neuroligins (NLGNs) are best characterized synaptic cell-adhesion molecules. They are part of excitatory glutamatergic and inhibitory GABAergic synapses in mammalian brain, medi...
  • Neuronal System, organism-specific biosystem (from REACTOME)
    Neuronal System, organism-specific biosystemThe human brain contains at least 100 billion neurons, each with the ability to influence many other cells. Clearly, highly sophisticated and efficient mechanisms are needed to enable communication a...
  • Protein-protein interactions at synapses, organism-specific biosystem (from REACTOME)
    Protein-protein interactions at synapses, organism-specific biosystemSynapses constitute highly specialized sites of asymmetric cell-cell adhesion and intercellular communication. Its formation involves the recruitment of presynaptic and postsynaptic molecules at newl...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled glutamate receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GKAP/Homer scaffold activity IEA
Inferred from Electronic Annotation
more info
 
actin binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IEA
Inferred from Electronic Annotation
more info
 
protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G protein-coupled glutamate receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
behavioral response to cocaine IEA
Inferred from Electronic Annotation
more info
 
calcium-mediated signaling using intracellular calcium source IEA
Inferred from Electronic Annotation
more info
 
chemical homeostasis within a tissue IEA
Inferred from Electronic Annotation
more info
 
negative regulation of calcineurin-NFAT signaling cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of interleukin-2 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
regulation of store-operated calcium entry IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sensory perception of sound IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
apical part of cell IEA
Inferred from Electronic Annotation
more info
 
cell junction IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
dendrite IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
postsynaptic density IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
stereocilium tip ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
homer protein homolog 2
Names
cupidin
homer homolog 2
homer homolog 3
homer scaffolding protein 2
homer, neuronal immediate early gene, 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029435.2 RefSeqGene

    Range
    5001..108748
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_004839.4NP_004830.2  homer protein homolog 2 isoform 1

    See identical proteins and their annotated locations for NP_004830.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1), also known as HOMER-2A, uses an alternate in-frame splice site in the central coding region, compared to variant 2, resulting in an isoform (1) that is shorter than isoform 2.
    Source sequence(s)
    BC012109
    Consensus CDS
    CCDS45336.1
    UniProtKB/Swiss-Prot
    Q9NSB8
    Related
    ENSP00000407634.2, ENST00000450735.6
    Conserved Domains (2) summary
    cd01206
    Location:3111
    EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain
    cl25732
    Location:149338
    SMC_N; RecF/RecN/SMC N terminal domain
  2. NM_199330.2NP_955362.1  homer protein homolog 2 isoform 2

    See identical proteins and their annotated locations for NP_955362.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), also known as HOMER-2B, represents the longer transcript and encodes the longer isoform (2).
    Source sequence(s)
    BI666912, CB321822, Y19026
    Consensus CDS
    CCDS45334.1
    UniProtKB/Swiss-Prot
    Q9NSB8
    Related
    ENSP00000305632.8, ENST00000304231.12
    Conserved Domains (2) summary
    cd01206
    Location:3111
    EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain
    cl25732
    Location:93333
    SMC_N; RecF/RecN/SMC N terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p12 Primary Assembly

    Range
    82836946..82986176 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011522232.2XP_011520534.1  homer protein homolog 2 isoform X1

    See identical proteins and their annotated locations for XP_011520534.1

    Conserved Domains (2) summary
    cd01206
    Location:13121
    EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain
    cl25732
    Location:103343
    SMC_N; RecF/RecN/SMC N terminal domain
  2. XM_006720775.3XP_006720838.1  homer protein homolog 2 isoform X1

    See identical proteins and their annotated locations for XP_006720838.1

    Conserved Domains (2) summary
    cd01206
    Location:13121
    EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain
    cl25732
    Location:103343
    SMC_N; RecF/RecN/SMC N terminal domain
  3. XM_006720776.4XP_006720839.1  homer protein homolog 2 isoform X3

    Conserved Domains (2) summary
    cd01206
    Location:3111
    EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain
    cl23720
    Location:221334
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
  4. XM_005272449.4XP_005272506.1  homer protein homolog 2 isoform X5

    See identical proteins and their annotated locations for XP_005272506.1

    Conserved Domains (2) summary
    cd01206
    Location:3111
    EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain
    cl25732
    Location:149338
    SMC_N; RecF/RecN/SMC N terminal domain
  5. XM_005272448.5XP_005272505.1  homer protein homolog 2 isoform X4

    Conserved Domains (2) summary
    cd01206
    Location:13121
    EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain
    cl25732
    Location:159348
    SMC_N; RecF/RecN/SMC N terminal domain
  6. XM_011522231.3XP_011520533.1  homer protein homolog 2 isoform X1

    See identical proteins and their annotated locations for XP_011520533.1

    Conserved Domains (2) summary
    cd01206
    Location:13121
    EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain
    cl25732
    Location:103343
    SMC_N; RecF/RecN/SMC N terminal domain
  7. XM_011522233.3XP_011520535.1  homer protein homolog 2 isoform X2

    Conserved Domains (2) summary
    cd01206
    Location:11119
    EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain
    cl23720
    Location:229342
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
  8. XM_011522234.3XP_011520536.1  homer protein homolog 2 isoform X6

    Conserved Domains (2) summary
    cd01206
    Location:287
    EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain
    cl23720
    Location:197310
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_199331.2: Suppressed sequence

    Description
    NM_199331.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
  2. NM_199332.2: Suppressed sequence

    Description
    NM_199332.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Support Center