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bhsA DUF1471 domain-containing multiple stress resistance outer membrane protein BhsA [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945492, updated on 26-Mar-2025

Summary

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Official Symbol
bhsA
Official Full Name
DUF1471 domain-containing multiple stress resistance outer membrane protein BhsA
Primary source
ECOCYC:G6570
Locus tag
b1112
See related
ASAP:ABE-0003758
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
comC; ECK1098; ycfR
Summary
Complex mutant phenotype includes sensitivity to acid, heat, hydrogen peroxide, and cadmium, as well as 5-fold increased biofilm in the presence of glucose, increased cell surface hydrophobicity, and increased aggregation; the mutant phenotype of enhanced biofilm formation upon stress is suppressed by exogenous indole or by a tnaA mutation (Zhang, 2007). [More information is available at EcoGene: EG13436]. BhsA appears to be a multiple stress resistance protein and is involved in biofilm formation . [More information is available at EcoCyc: G6570].
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Genomic context

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Sequence:
NC_000913.3 (1169073..1169330)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene PF05433 family protein YcfJ Neighboring gene DNA-binding transcriptional repressor ComR Neighboring gene ncRNA Neighboring gene L,D-transpeptidase LdtC Neighboring gene transcription-repair coupling factor

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome-wide expression profiling in Escherichia coli K-12. Richmond CS, et al. Nucleic Acids Res, 1999 Oct 1. PMID 10481021, Free PMC Article
  2. Role of the extracytoplasmic function protein family sigma factor RpoE in metal resistance of Escherichia coli. Egler M, et al. J Bacteriol, 2005 Apr. PMID 15774872, Free PMC Article
  3. pH regulates genes for flagellar motility, catabolism, and oxidative stress in Escherichia coli K-12. Maurer LM, et al. J Bacteriol, 2005 Jan. PMID 15601715, Free PMC Article
  4. Genome-wide transcriptional profiling of the Escherichia coli responses to superoxide stress and sodium salicylate. Pomposiello PJ, et al. J Bacteriol, 2001 Jul. PMID 11395452, Free PMC Article
  5. Exploring the antimicrobial action of a carbon monoxide-releasing compound through whole-genome transcription profiling of Escherichia coli. Nobre LS, et al. Microbiology (Reading), 2009 Mar. PMID 19246752

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ComC is an outer membrane protein which lowers the permeability of the outer membrane to copper, and its expression is controlled by ComR, a novel, TetR-like copper-responsive repressor.
    Title: The copper-inducible ComR (YcfQ) repressor regulates expression of ComC (YcfR), which affects copper permeability of the outer membrane of Escherichia coli.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Process Evidence Code Pubs
acts_upstream_of_or_within response to copper ion IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within response to copper ion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to stress IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within response to stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within single-species biofilm formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell outer membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell outer membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
DUF1471 domain-containing multiple stress resistance outer membrane protein BhsA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1169073..1169330
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415630.1 DUF1471 domain-containing multiple stress resistance outer membrane protein BhsA [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415630.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A2X1PV63
    Conserved Domains (1) summary
    pfam07338
    Location:33 → 84
    DUF1471; Protein of unknown function (DUF1471)
Nucleotide Protein
Heading Accession and Version

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