grxA reduced glutaredoxin 1 [Escherichia coli str. K-12 substr. MG1655] - Gene

Summary

Official Symbol: grxA
Official Full Name: reduced glutaredoxin 1
Primary source: ECOCYC:EG10417
Locus tag: b0849
See related: ASAP:ABE-0002893
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage: Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as: ECK0840; grx
Summary: Glutaredoxins are ubiquitous proteins that catalyze the reduction of disulfides via reduced glutathione (GSH). [More information is available at EcoCyc: EG10417].
: Try the new Gene page
Try the new Transcripts and proteins table

NC_000913.3 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

grxA plays a role in E. coli resistance to distant UV irradiation and in regulation of SOS response.
Title: [The role of thiol redox systems in response of Escherichia coli to distant UV irradiation].
N-terminus verified by Edman degradation on complete protein
Title: The primary structure of Escherichia coli glutaredoxin. Distant homology with thioredoxins in a superfamily of small proteins with a redox-active cystine disulfide/cysteine dithiol.
in contrast to the glutaredoxin-glutathione mixed disulfide intermediate, the only intermediate in the protein disulfide isomerases (PDI)-catalyzed reaction was PDI peptide mixed disulfide
Title: Insights into deglutathionylation reactions. Different intermediates in the glutaredoxin and protein disulfide isomerase catalyzed reactions are defined by the gamma-linkage present in glutathione.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables disulfide oxidoreductase activity	IDA Inferred from Direct Assay more info	PubMed
enables electron transfer activity	IEA Inferred from Electronic Annotation more info
enables glutathione disulfide oxidoreductase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-disulfide reductase (glutathione) activity	IDA Inferred from Direct Assay more info	PubMed
enables protein-disulfide reductase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein-disulfide reductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell redox homeostasis	IEA Inferred from Electronic Annotation more info
involved_in cellular response to oxidative stress	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cellular response to oxidative stress	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within deoxyribonucleotide biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed