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acrD multidrug efflux pump RND permease AcrD [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945464, updated on 9-Mar-2022

Summary

Gene symbol
acrD
Gene description
multidrug efflux pump RND permease AcrD
Primary source
ASAP:ABE-0008136
Locus tag
b2470
See related
ECOCYC:EG10014
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2465; yffA
Summary
acrD mutation confers increased sensitivity to aminoglycosides. acrD is paralogous to acrB. [More information is available at EcoGene: EG10014]. [More information is available at EcoCyc: EG10014].
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Genomic context

Sequence:
NC_000913.3 (2587595..2590708)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative oxidoreductase AegA Neighboring gene sensor histidine kinase NarQ Neighboring gene uncharacterized protein YpfM Neighboring gene putative reductase YffB

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables bile acid transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables efflux transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables xenobiotic transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
multidrug efflux pump RND permease AcrD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2587595..2590708
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416965.1 multidrug efflux pump RND permease AcrD [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416965.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P24177
    Conserved Domains (1) summary
    PRK10555
    Location:11037
    PRK10555; multidrug efflux RND transporter permease AcrD