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moeA molybdopterin molybdotransferase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945454, updated on 6-Jul-2026
Official Symbol
moeA
Official Full Name
molybdopterin molybdotransferase
Primary source
ECOCYC:EG10153
Locus tag
b0827
See related
ASAP:ABE-0002823
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
bisB; chlE; ECK0817; narE
Summary
Human gephyrin resembles a fused MoeA and Mog. [More information is available at EcoGene: EG10153]. Molybdenum and tungsten cofactors of all enzymes, with the exception of nitrogenase, that require one or the other of the other for activity are present in an oxidized state as molybdate or tungstate ions that are chelated by the cis-dithiolene moiety of a molybdenum cofactor. [More information is available at EcoCyc: EG10153].
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Sequence:
NC_000913.3 (865129..866364, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene fructose-6-phosphate aldolase 1 Neighboring gene molybdopterin-synthase adenylyltransferase Neighboring gene isoaspartyl dipeptidase proenzyme Neighboring gene glutathione ABC transporter ATP binding subunit GsiA Neighboring gene glutathione ABC transporter periplasmic binding protein

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Involvement of a gene of the chl E locus in the regulation of the nitrate reductase operon. Pascal MC, et al. Mol Gen Genet, 1982. PMID 7045588
  2. Transcriptional regulation of the moe (molybdate metabolism) operon of Escherichia coli. Hasona A, et al. Arch Microbiol, 2001 Mar. PMID 11357510
  3. Hypersensitivity of Escherichia coli Delta(uvrB-bio) mutants to 6-hydroxylaminopurine and other base analogs is due to a defect in molybdenum cofactor biosynthesis. Kozmin SG, et al. J Bacteriol, 2000 Jun. PMID 10852865, Free PMC Article
  4. Functional analysis of the Escherichia coli molybdopterin cofactor biosynthesis protein MoeA by site-directed mutagenesis. Sandu C, et al. Biol Chem, 2002 Feb. PMID 11934270
  5. Physiological and genetic analyses leading to identification of a biochemical role for the moeA (molybdate metabolism) gene product in Escherichia coli. Hasona A, et al. J Bacteriol, 1998 Mar. PMID 9515915, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Two different functional areas were assigned to regions at or near the MoeA active site cleft
    Title: Mutational analysis of Escherichia coli MoeA: two functional activities map to the active site cleft.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables molybdopterin molybdotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molybdopterin molybdotransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables molybdopterin molybdotransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in Mo-molybdopterin cofactor biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within Mo-molybdopterin cofactor biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in Mo-molybdopterin cofactor biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within Mo-molybdopterin cofactor biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within molybdenum incorporation into molybdenum-molybdopterin complex IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in molybdopterin cofactor biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
molybdopterin molybdotransferase
NP_415348.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    865129..866364 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415348.1 molybdopterin molybdotransferase

    See identical proteins and their annotated locations for NP_415348.1

    Status: REVIEWED

    Conserved Domains (1) summary
    PRK10680
    Location:1 → 411
    PRK10680; molybdopterin biosynthesis protein MoeA; Provisional
Nucleotide Protein
Heading Accession and Version

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