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clsB cardiolipin synthase B [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945409, updated on 26-Mar-2025
Official Symbol
clsB
Official Full Name
cardiolipin synthase B
Primary source
ECOCYC:G6406
Locus tag
b0789
See related
ASAP:ABE-0002692
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0778; ybhO
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Sequence:
NC_000913.3 (822498..823739, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene Bax1-I family protein YbhL Neighboring gene Bax1-I family protein YbhM Neighboring gene PF03706 family inner membrane protein YbhN Neighboring gene endonuclease/exonuclease/phosphatase domain-containing protein YbhP Neighboring gene inner membrane protein YbhQ Neighboring gene ABC exporter membrane subunit YbhR Neighboring gene ABC exporter membrane subunit YbhS Neighboring gene ABC exporter ATP binding subunit YbhF

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. In Vivo and in Vitro Synthesis of Phosphatidylglycerol by an Escherichia coli Cardiolipin Synthase. Li C, et al. J Biol Chem, 2016 Nov 25. PMID 27760827, Free PMC Article
  2. Cardiolipin synthases of Escherichia coli have phospholipid class specific phospholipase D activity dependent on endogenous and foreign phospholipids. Jeucken A, et al. Biochim Biophys Acta Mol Cell Biol Lipids, 2018 Oct. PMID 29933046
  3. A second Escherichia coli protein with CL synthase activity. Guo D, et al. Biochim Biophys Acta, 2000 Jan 17. PMID 10634942
  4. Sequences that direct significant levels of frameshifting are frequent in coding regions of Escherichia coli. Gurvich OL, et al. EMBO J, 2003 Nov 3. PMID 14592990, Free PMC Article
  5. Discovery of a cardiolipin synthase utilizing phosphatidylethanolamine and phosphatidylglycerol as substrates. Tan BK, et al. Proc Natl Acad Sci U S A, 2012 Oct 9. PMID 22988102, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Study demonstrated that ClsB is clearly is to perform headgroup exchange on endogenous phospholipids, as demonstrated for a variety of primary alcohols.
    Title: Cardiolipin synthases of Escherichia coli have phospholipid class specific phospholipase D activity dependent on endogenous and foreign phospholipids.
  2. the expression of E. coli ClsB significantly increased PG and cardiolipin levels, with the growth deficiency of pgsA null strain also being complemented under such conditions. Identification of this alternative mechanism for PG synthesis not only expands our knowledge of bacterial anionic phospholipid biosynthesis
    Title: In Vivo and in Vitro Synthesis of Phosphatidylglycerol by an Escherichia coli Cardiolipin Synthase.
  3. Data indicate that the cardiolipin synthase DeltaclsABC mutant (clsA, clsB(ybhO) and clsC (ymdC))nlacks detectible cardiolipin (CL) regardless of growth phase or growth conditions.
    Title: Discovery of a cardiolipin synthase utilizing phosphatidylethanolamine and phosphatidylglycerol as substrates.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables cardiolipin synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cardiolipin synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cardiolipin synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables phospholipase D activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphotransferase activity, for other substituted phosphate groups IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cardiolipin biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cardiolipin biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cardiolipin biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
cardiolipin synthase B
NP_415310.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    822498..823739 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415310.1 cardiolipin synthase B [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415310.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8T6BI63
    Conserved Domains (1) summary
    PRK11263
    Location:2 → 412
    PRK11263; cardiolipin synthase ClsB
Nucleotide Protein
Heading Accession and Version

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