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moaC cyclic pyranopterin monophosphate synthase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945397, updated on 20-Feb-2025

Summary

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Official Symbol
moaC
Official Full Name
cyclic pyranopterin monophosphate synthase
Primary source
ECOCYC:EG11666
Locus tag
b0783
See related
ASAP:ABE-0002673
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
chlA3; ECK0772
Summary
Molybdenum and tungsten cofactors of all enzymes, with the exception of nitrogenase, that require one or the other of the other them for activity are present in an oxidized state as molybdate or tungstate ions that are chelated by the cis-dithiolene moiety of a molybdenum cofactor. [More information is available at EcoCyc: EG11666].
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Genomic context

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Sequence:
NC_000913.3 (818570..819055)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene GTP 3',8'-cyclase Neighboring gene protein MoaB Neighboring gene molybdopterin synthase sulfur carrier subunit Neighboring gene molybdopterin synthase catalytic subunit Neighboring gene Bax1-I family protein YbhL

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mechanistic Investigation of cPMP Synthase in Molybdenum Cofactor Biosynthesis Using an Uncleavable Substrate Analogue. Hover BM, et al. Biochemistry, 2015 Dec 15. PMID 26575208, Free PMC Article
  2. Insights into molybdenum cofactor deficiency provided by the crystal structure of the molybdenum cofactor biosynthesis protein MoaC. Wuebbens MM, et al. Structure, 2000 Jul 15. PMID 10903949
  3. Mechanism of pyranopterin ring formation in molybdenum cofactor biosynthesis. Hover BM, et al. Proc Natl Acad Sci U S A, 2015 May 19. PMID 25941396, Free PMC Article
  4. Assembly reflects evolution of protein complexes. Levy ED, et al. Nature, 2008 Jun 26. PMID 18563089, Free PMC Article
  5. Rearrangement reactions in the biosynthesis of molybdopterin--an NMR study with multiply 13C/15N labelled precursors. Rieder C, et al. Eur J Biochem, 1998 Jul 1. PMID 9692897

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MS analysis of MoaC treated with 3',8-cH2GMP[CH2]PP provided strong evidence that compound Y forms a tight complex with MoaC likely through a covalent linkage.
    Title: Mechanistic Investigation of cPMP Synthase in Molybdenum Cofactor Biosynthesis Using an Uncleavable Substrate Analogue.
  2. N-terminus verified by Edman degradation on mature peptide
    Title: Molecular genetic analysis of the moa operon of Escherichia coli K-12 required for molybdenum cofactor biosynthesis.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables cyclic pyranopterin monophosphate synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cyclic pyranopterin monophosphate synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Mo-molybdopterin cofactor biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within Mo-molybdopterin cofactor biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
cyclic pyranopterin monophosphate synthase
NP_415304.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    818570..819055
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415304.1 cyclic pyranopterin monophosphate synthase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415304.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0AAJ3P0B5
    Conserved Domains (1) summary
    PRK09364
    Location:1 → 159
    moaC; cyclic pyranopterin monophosphate synthase MoaC
Nucleotide Protein
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