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moaA GTP 3',8'-cyclase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945392, updated on 19-Nov-2025
Official Symbol
moaA
Official Full Name
GTP 3',8'-cyclase
Primary source
ECOCYC:EG11595
Locus tag
b0781
See related
ASAP:ABE-0002669
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
bisA; chlA; chlA1; ECK0770; narA
Summary
The moaA 5' UTR has a molybdenum cofactor (Moco) sensitive riboswitch. [More information is available at EcoGene: EG11595]. Molybdenum and tungsten cofactors of all enzymes, with the exception of nitrogenase, that require one or the other of the other for activity are present in an oxidized state as molybdate or tungstate ions that are chelated by the cis-dithiolene moiety of a molybdenum cofactor. [More information is available at EcoCyc: EG11595].
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Sequence:
NC_000913.3 (817044..818033)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene UvrABC excision nuclease subunit B Neighboring gene putative transferase YbhK Neighboring gene protein MoaB Neighboring gene cyclic pyranopterin monophosphate synthase Neighboring gene molybdopterin synthase sulfur carrier subunit

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. A widespread riboswitch candidate that controls bacterial genes involved in molybdenum cofactor and tungsten cofactor metabolism. Regulski EE, et al. Mol Microbiol, 2008 May. PMID 18363797, Free PMC Article
  2. Positive selection of mutants with deletions of the gal-chl region of the Salmonella chromosome as a screening procedure for mutagens that cause deletions. Alper MD, et al. J Bacteriol, 1975 Jan. PMID 1090571, Free PMC Article
  3. Synthesis of nitrate reductase components in chlorate-resistant mutants of Escherichia coli. MacGregor CH. J Bacteriol, 1975 Mar. PMID 1090592, Free PMC Article
  4. The tetrahydropyranopterin structure of the sulfur-free and metal-free molybdenum cofactor precursor. Santamaria-Araujo JA, et al. J Biol Chem, 2004 Apr 16. PMID 14761975
  5. Regulation of the chlA locus of Escherichia coli K12: involvement of molybdenum cofactor. Baker KP, et al. Mol Microbiol, 1991 Apr. PMID 1906967

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on complete protein
    Title: Molecular genetic analysis of the moa operon of Escherichia coli K-12 required for molybdenum cofactor biosynthesis.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables 4 iron, 4 sulfur cluster binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables GTP 3',8'-cyclase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP 3',8'-cyclase activity IEA
Inferred from Electronic Annotation
more info
  
enables GTP 3',8'-cyclase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables S-adenosyl-L-methionine binding IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables cyclic pyranopterin monophosphate synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in Mo-molybdopterin cofactor biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Mo-molybdopterin cofactor biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within Mo-molybdopterin cofactor biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in molybdopterin cofactor biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to heat IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Preferred Names
GTP 3',8'-cyclase
NP_415302.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    817044..818033
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415302.1 GTP 3',8'-cyclase

    See identical proteins and their annotated locations for NP_415302.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A454A2F5
    Conserved Domains (1) summary
    PRK00164
    Location:1 → 329
    moaA; GTP 3',8-cyclase MoaA
Nucleotide Protein
Heading Accession and Version

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