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moaA GTP 3',8'-cyclase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945392, updated on 19-Sep-2024

Summary

Official Symbol
moaA
Official Full Name
GTP 3',8'-cyclase
Primary source
ECOCYC:EG11595
Locus tag
b0781
See related
ASAP:ABE-0002669
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
bisA; chlA; chlA1; ECK0770; narA
Summary
The moaA 5' UTR has a molybdenum cofactor (Moco) sensitive riboswitch. [More information is available at EcoGene: EG11595]. Molybdenum and tungsten cofactors of all enzymes, with the exception of nitrogenase, that require one or the other of the other for activity are present in an oxidized state as molybdate or tungstate ions that are chelated by the cis-dithiolene moiety of a molybdenum cofactor. [More information is available at EcoCyc: EG11595].
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Genomic context

Sequence:
NC_000913.3 (817044..818033)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene UvrABC excision nuclease subunit B Neighboring gene putative transferase YbhK Neighboring gene protein MoaB Neighboring gene cyclic pyranopterin monophosphate synthase Neighboring gene molybdopterin synthase sulfur carrier subunit

Pathways from PubChem

General gene information

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 
enables 4 iron, 4 sulfur cluster binding ISO
Inferred from Sequence Orthology
more info
PubMed 
enables GTP 3',8'-cyclase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTP 3',8'-cyclase activity IEA
Inferred from Electronic Annotation
more info
 
enables GTP 3',8'-cyclase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 
enables S-adenosyl-L-methionine binding IEA
Inferred from Electronic Annotation
more info
 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables cyclic pyranopterin monophosphate synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
GTP 3',8'-cyclase
NP_415302.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    817044..818033
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415302.1 GTP 3',8'-cyclase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415302.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A454A2F5
    Conserved Domains (1) summary
    PRK00164
    Location:1329
    moaA; GTP 3',8-cyclase MoaA