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bioD dethiobiotin synthetase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945387, updated on 19-Sep-2024

Summary

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Official Symbol
bioD
Official Full Name
dethiobiotin synthetase
Primary source
ECOCYC:EG10120
Locus tag
b0778
See related
ASAP:ABE-0002650
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0767
Summary
False positive lipoprotein prediction, verified amino terminus, Met is cleaved. [More information is available at EcoGene: EG10120]. Dethiobiotin synthetase catalyzes the first ring closure in the biosynthesis of biotin, which is the penultimate step in the biosynthesis pathway. [More information is available at EcoCyc: EG10120].
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Genomic context

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Sequence:
NC_000913.3 (812270..812947)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene adenosylmethionine-8-amino-7-oxononanoate aminotransferase Neighboring gene biotin synthase Neighboring gene 8-amino-7-oxononanoate synthase Neighboring gene malonyl-acyl carrier protein methyltransferase Neighboring gene UvrABC excision nuclease subunit B Neighboring gene putative transferase YbhK

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structure of dethiobiotin synthetase at 0.97 A resolution. Sandalova T, et al. Acta Crystallogr D Biol Crystallogr, 1999 Mar. PMID 10089457
  2. Crystal structure of two quaternary complexes of dethiobiotin synthetase, enzyme-MgADP-AlF3-diaminopelargonic acid and enzyme-MgADP-dethiobiotin-phosphate; implications for catalysis. Käck H, et al. Protein Sci, 1998 Dec. PMID 9865950, Free PMC Article
  3. Snapshot of a phosphorylated substrate intermediate by kinetic crystallography. Käck H, et al. Proc Natl Acad Sci U S A, 1998 May 12. PMID 9576910, Free PMC Article
  4. Isolation and chemistry of the mixed anhydride intermediate in the reaction catalyzed by dethiobiotin synthetase. Gibson KJ. Biochemistry, 1997 Jul 15. PMID 9214291
  5. Structure of ATP-dependent carboxylase, dethiobiotin synthase. Schneider G, et al. Methods Enzymol, 1997. PMID 9211290

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on mature peptide
    Title: Sequence and crystallization of Escherichia coli dethiobiotin synthetase, the penultimate enzyme of biotin biosynthesis.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General protein information

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Preferred Names
dethiobiotin synthetase
NP_415299.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    812270..812947
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415299.1 dethiobiotin synthetase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415299.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A828NVR5
    Conserved Domains (1) summary
    COG0132
    Location:1 → 225
    BioD; Dethiobiotin synthetase [Coenzyme transport and metabolism]
Nucleotide Protein
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