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bioF 8-amino-7-oxononanoate synthase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945384, updated on 26-Mar-2025

Summary

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Official Symbol
bioF
Official Full Name
8-amino-7-oxononanoate synthase
Primary source
ECOCYC:EG10121
Locus tag
b0776
See related
ASAP:ABE-0002646
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0765
Summary
8-Amino-7-oxononanoate synthase catalyzes the first committed step in biotin biosynthesis, the decarboxylative condensation of L-alanine and 6-carboxyhexanoyl-CoA . [More information is available at EcoCyc: EG10121].
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Genomic context

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Sequence:
NC_000913.3 (810381..811535)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative kinase inhibitor Neighboring gene adenosylmethionine-8-amino-7-oxononanoate aminotransferase Neighboring gene biotin synthase Neighboring gene malonyl-acyl carrier protein methyltransferase Neighboring gene dethiobiotin synthetase Neighboring gene UvrABC excision nuclease subunit B

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. An early intermediate in the biosynthesis of biotin: Incorporation studies with [1,7-C(2)]pimelic acid. Eisenberg MA, et al. Biochem J, 1966 Dec. PMID 16742432, Free PMC Article
  2. Preparation of pimeloyl-coenzyme A. Eisenberg MA. Methods Enzymol, 1979. PMID 440115
  3. Mechanism of 8-amino-7-oxononanoate synthase: spectroscopic, kinetic, and crystallographic studies. Webster SP, et al. Biochemistry, 2000 Jan 25. PMID 10642176
  4. Suicide inhibition of alpha-oxamine synthases: structures of the covalent adducts of 8-amino-7-oxononanoate synthase with trifluoroalanine. Alexeev D, et al. Org Biomol Chem, 2006 Apr 7. PMID 16557306
  5. Functional asymmetry for the active sites of linked 5-aminolevulinate synthase and 8-amino-7-oxononanoate synthase. Turbeville TD, et al. Arch Biochem Biophys, 2011 Jul. PMID 21600186, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 8-amino-7-oxononanoate synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 8-amino-7-oxononanoate synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 8-amino-7-oxononanoate synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables pyridoxal phosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in biotin biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in biotin biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in biotin biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
8-amino-7-oxononanoate synthase
NP_415297.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    810381..811535
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415297.1 8-amino-7-oxononanoate synthase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415297.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8T5ZR45
    Conserved Domains (1) summary
    PRK05958
    Location:1 → 382
    PRK05958; 8-amino-7-oxononanoate synthase; Reviewed
Nucleotide Protein
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