U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

bioF 8-amino-7-oxononanoate synthase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945384, updated on 2-May-2024

Summary

Gene symbol
bioF
Gene description
8-amino-7-oxononanoate synthase
Primary source
ASAP:ABE-0002646
Locus tag
b0776
See related
ECOCYC:EG10121
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0765
Summary
8-Amino-7-oxononanoate synthase catalyzes the first committed step in biotin biosynthesis, the decarboxylative condensation of L-alanine and 6-carboxyhexanoyl-CoA . [More information is available at EcoCyc: EG10121].
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Sequence:
NC_000913.3 (810381..811535)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative kinase inhibitor Neighboring gene adenosylmethionine-8-amino-7-oxononanoate aminotransferase Neighboring gene biotin synthase Neighboring gene malonyl-acyl carrier protein methyltransferase Neighboring gene dethiobiotin synthetase Neighboring gene UvrABC excision nuclease subunit B

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 8-amino-7-oxononanoate synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables 8-amino-7-oxononanoate synthase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables 8-amino-7-oxononanoate synthase activity IEA
Inferred from Electronic Annotation
more info
 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
enables pyridoxal phosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in biotin biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in biotin biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in biotin biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 

General protein information

Preferred Names
8-amino-7-oxononanoate synthase
NP_415297.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    810381..811535
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415297.1 8-amino-7-oxononanoate synthase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415297.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8T5ZR45
    Conserved Domains (1) summary
    PRK05958
    Location:1382
    PRK05958; 8-amino-7-oxononanoate synthase; Reviewed