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rsuA 16S rRNA pseudouridine(516) synthase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945378, updated on 3-Dec-2024

Summary

Official Symbol
rsuA
Official Full Name
16S rRNA pseudouridine(516) synthase
Primary source
ECOCYC:EG12044
Locus tag
b2183
See related
ASAP:ABE-0007223
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2177; yejD
Summary
RsuA is a survival protein required for MazF-mediated survival of a small subpopulation after inhibition of translation (Amitai, 2009). [More information is available at EcoGene: EG12044]. RsuA is the pseudouridine synthase that is responsible for pseudouridylation of 16S rRNA at position 516 . [More information is available at EcoCyc: EG12044].
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Genomic context

Sequence:
NC_000913.3 (2279788..2280483, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene protein YejG Neighboring gene multidrug efflux pump Bcr Neighboring gene putative DNA repair helicase RadD Neighboring gene 50S ribosomal subunit protein L25

General gene information

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 16S rRNA pseudouridine(516) synthase activity IEA
Inferred from Electronic Annotation
more info
 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables pseudouridine synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables pseudouridine synthase activity IEA
Inferred from Electronic Annotation
more info
 
enables rRNA pseudouridine synthase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables rRNA pseudouridine synthase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in enzyme-directed rRNA pseudouridine synthesis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in enzyme-directed rRNA pseudouridine synthesis IEA
Inferred from Electronic Annotation
more info
 
involved_in enzyme-directed rRNA pseudouridine synthesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in pseudouridine synthesis IEA
Inferred from Electronic Annotation
more info
 
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
16S rRNA pseudouridine(516) synthase
NP_416688.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2279788..2280483 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416688.1 16S rRNA pseudouridine(516) synthase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416688.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A6C9QHK6
    Conserved Domains (1) summary
    PRK10839
    Location:1230
    PRK10839; 16S rRNA pseudouridine(516) synthase RsuA