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mngR DNA-binding transcriptional repressor MngR [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945371, updated on 6-Jul-2026
Official Symbol
mngR
Official Full Name
DNA-binding transcriptional repressor MngR
Primary source
ECOCYC:EG11109
Locus tag
b0730
See related
ASAP:ABE-0002487
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0718; farR; ybgB
Summary
Originally identifed as a fatty acyl-responsive regulator FarR based on in vitro experiments; this conclusion is now in doubt based on microarray experiments. [More information is available at EcoGene: EG11109]. According to microarray analysis, the "mannosyl-d-glycerate regulator," MngR, regulates only two genes, mngA and mngB, involved in 2-O--mannosyl-d-glycerate utilization . [More information is available at EcoCyc: EG11109].
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Sequence:
NC_000913.3 (765153..765875, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene succinyl-CoA synthetase subunit beta Neighboring gene succinyl-CoA synthetase subunit alpha Neighboring gene ncRNA Neighboring gene 2-O-alpha-mannosyl-D-glycerate specific PTS enzyme II Neighboring gene alpha-mannosidase

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Identification of a fatty acyl responsive regulator (FarR) in Escherichia coli. Quail MA, et al. FEBS Lett, 1994 Dec 19. PMID 7805834
  2. Isolation and characterization of the heat-responsive genes in Escherichia coli. Utsumi R, et al. Biosci Biotechnol Biochem, 1996 Feb. PMID 9063979
  3. Overexpression and site-directed mutagenesis of the succinyl-CoA synthetase of Escherichia coli and nucleotide sequence of a gene (g30) that is adjacent to the suc operon. Buck D, et al. Biochem J, 1989 Jun 15. PMID 2548486, Free PMC Article
  4. Phosphotransferase-mediated transport of the osmolyte 2-O-alpha-mannosyl-D-glycerate in Escherichia coli occurs by the product of the mngA (hrsA) gene and is regulated by the mngR (farR) gene product acting as repressor. Sampaio MM, et al. J Biol Chem, 2004 Feb 13. PMID 14645248
  5. Inferring gene function from evolutionary change in signatures of translation efficiency. Krisko A, et al. Genome Biol, 2014 Mar 3. PMID 24580753, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to heat IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Preferred Names
DNA-binding transcriptional repressor MngR

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    765153..765875 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415258.1 DNA-binding transcriptional repressor MngR

    See identical proteins and their annotated locations for NP_415258.1

    Status: REVIEWED

    Conserved Domains (1) summary
    PRK09764
    Location:1 → 240
    PRK09764; GntR family transcriptional regulator
Nucleotide Protein
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