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qseB [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945369, updated on 11-Sep-2024

Summary

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Official Symbol
qseB
Primary source
ECOCYC:G7575
Locus tag
b3025
See related
ASAP:ABE-0009936
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3016; ygiX
Summary
QseB, "quorum-sensing Escherichia coli regulator B", is the response regulator component of the QseB-QseC two-component system, which is one component of the quorum-sensing regulatory cascade involved in the positive regulation of flagella and motility genes by activating transcription of flhDC, an operon that encodes the master regulator of these genes . [More information is available at EcoCyc: G7575].
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Genomic context

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Sequence:
NC_000913.3 (3169828..3170487)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional repressor YgiV Neighboring gene BOF family protein YgiW Neighboring gene sensor histidine kinase QseC Neighboring gene DUF2645 domain-containing inner membrane protein YgiZ Neighboring gene NADPH:quinone oxidoreductase MdaB

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Nanoalumina triggers the antibiotic persistence of Escherichia coli through quorum sensing regulators lrsF and qseB. Wang S, et al. J Hazard Mater, 2022 Aug 15. PMID 35739728
  2. The Escherichia coli QseB/QseC signaling is required for correct timing of replication initiation and cell motility. Wu D, et al. Gene, 2021 Mar 20. PMID 33359126
  3. Escherichia coli O157:H7 lacking the qseBC-encoded quorum-sensing system outcompetes the parental strain in colonization of cattle intestines. Sharma VK, et al. Appl Environ Microbiol, 2014 Mar. PMID 24413602, Free PMC Article
  4. QseC-mediated dephosphorylation of QseB is required for expression of genes associated with virulence in uropathogenic Escherichia coli. Kostakioti M, et al. Mol Microbiol, 2009 Sep. PMID 19703104, Free PMC Article
  5. Transcriptional autoregulation by quorum sensing Escherichia coli regulators B and C (QseBC) in enterohaemorrhagic E. coli (EHEC). Clarke MB, et al. Mol Microbiol, 2005 Oct. PMID 16194231

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Nanoalumina triggers the antibiotic persistence of Escherichia coli through quorum sensing regulators lrsF and qseB.
    Title: Nanoalumina triggers the antibiotic persistence of Escherichia coli through quorum sensing regulators lrsF and qseB.
  2. The Escherichia coli QseB/QseC signaling is required for correct timing of replication initiation and cell motility.
    Title: The Escherichia coli QseB/QseC signaling is required for correct timing of replication initiation and cell motility.
  3. study concludes that cross talk between the regulatory systems for virulence and metabolism of aromatic amines may depend upon the ability of QseBC and, to a lesser extent QseF, to regulate feaR as well as genes directly involved in virulence
    Title: Conversion of Norepinephrine to 3,4-Dihdroxymandelic Acid in Escherichia coli Requires the QseBC Quorum-Sensing System and the FeaR Transcription Factor.
  4. All components of the QseBC and PmrAB two-component systems (TCSs) are required for proper response to ferric iron.
    Title: Signaling by two-component system noncognate partners promotes intrinsic tolerance to polymyxin B in uropathogenic Escherichia coli.
  5. The presence of one sensor kinase, QseC, is required to regulate the interaction between the other sensor kinase, PmrB and the response regulators from both systems, QseB and PmrA, effectively creating a "four-component" system required for virulence.
    Title: The Histidine Residue of QseC Is Required for Canonical Signaling between QseB and PmrB in Uropathogenic Escherichia coli.
  6. Near-parental level of motility, ability to respond to norepinephrine, and enhanced expression of locus of enterocyte effacement and curli genes might in part be responsible for increased colonization and fecal shedding of the qseBC mutant in calves.
    Title: Escherichia coli O157:H7 lacking the qseBC-encoded quorum-sensing system outcompetes the parental strain in colonization of cattle intestines.
  7. The authors discovered that QseC has phosphatase activity required for QseB dephosphorylation.
    Title: QseC-mediated dephosphorylation of QseB is required for expression of genes associated with virulence in uropathogenic Escherichia coli.
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Pathways from PubChem

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General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphorelay response regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription cis-regulatory region binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA-templated transcription EXP
Inferred from Experiment
more info
 PubMed 
involved_in phosphorelay signal transduction system IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to metal ion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein-DNA complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
DNA-binding transcriptional activator QseB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3169828..3170487
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417497.1 DNA-binding transcriptional activator QseB [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417497.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A5B9AQQ5
    Conserved Domains (1) summary
    PRK10336
    Location:1 → 219
    PRK10336; two-component system response regulator QseB
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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