U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

cueR DNA-binding transcriptional dual regulator CueR [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945332, updated on 30-Jul-2025
Official Symbol
cueR
Official Full Name
DNA-binding transcriptional dual regulator CueR
Primary source
ECOCYC:G6263
Locus tag
b0487
See related
ASAP:ABE-0001693
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
copR; ECK0481; ybbI
Try the new Gene page
Try the new Transcripts and proteins table
Sequence:
NC_000913.3 (513993..514400)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene glutaminase 1 Neighboring gene putative transporter YbaT Neighboring gene NfeD-like family protein YbbJ Neighboring gene PHB domain-containing protein QmcA Neighboring gene putative iron ABC exporter ATP-binding subunit FetA Neighboring gene putative iron ABC exporter membrane subunit FetB

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. CueR activates transcription through a DNA distortion mechanism. Fang C, et al. Nat Chem Biol, 2021 Jan. PMID 32989300, Free PMC Article
  2. TRANSCRIPTION. Allosteric transcriptional regulation via changes in the overall topology of the core promoter. Philips SJ, et al. Science, 2015 Aug 21. PMID 26293965, Free PMC Article
  3. Single-molecule study of metalloregulator CueR-DNA interactions using engineered Holliday junctions. Andoy NM, et al. Biophys J, 2009 Aug 5. PMID 19651042, Free PMC Article
  4. Tying Up a Loose End: On the Role of the C-Terminal CCHHRAG Fragment of the Metalloregulator CueR. Balogh RK, et al. Chembiochem, 2022 Aug 17. PMID 35714117, Free PMC Article
  5. An atypical linear Cu(I)-S2 center constitutes the high-affinity metal-sensing site in the CueR metalloregulatory protein. Chen K, et al. J Am Chem Soc, 2003 Oct 8. PMID 14518983

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Tying Up a Loose End: On the Role of the C-Terminal CCHHRAG Fragment of the Metalloregulator CueR.
    Title: Tying Up a Loose End: On the Role of the C-Terminal CCHHRAG Fragment of the Metalloregulator CueR.
  2. CueR activates transcription through a DNA distortion mechanism.
    Title: CueR activates transcription through a DNA distortion mechanism.
  3. Data indicate that RNAP sigma(70)-can bind to copper efflux regulator (CueR)-promoter PcopA complex.
    Title: Metalloregulator CueR biases RNA polymerase's kinetic sampling of dead-end or open complex to repress or activate transcription.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription activator activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables copper ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables copper ion binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transcription cis-regulatory region binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA-templated transcription EXP
Inferred from Experiment
more info
 PubMed 
acts_upstream_of_or_within DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within DNA-templated transcription IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of protein-DNA complex IPI
Inferred from Physical Interaction
more info
 PubMed 
Preferred Names
DNA-binding transcriptional dual regulator CueR

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    513993..514400
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415020.1 DNA-binding transcriptional dual regulator CueR

    See identical proteins and their annotated locations for NP_415020.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1V2G3D4, A0A5B9AKM8
    Conserved Domains (1) summary
    PRK10227
    Location:1 → 135
    PRK10227; HTH-type transcriptional regulator CueR
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.