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hycC formate hydrogenlyase subunit HycC [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945327, updated on 25-Jun-2025
Official Symbol
hycC
Official Full Name
formate hydrogenlyase subunit HycC
Primary source
ECOCYC:EG10476
Locus tag
b2723
See related
ASAP:ABE-0008948
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2718; hevC
Summary
FhlA regulon. [More information is available at EcoGene: EG10476]. HycC encodes an extremely hydrophobic protein with 12 to 16 predicted transmembrane domains. [More information is available at EcoCyc: EG10476].
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Sequence:
NC_000913.3 (2847415..2849241, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene formate hydrogenlyase subunit HycE Neighboring gene formate hydrogenlyase subunit HycD Neighboring gene formate hydrogenlyase subunit HycB Neighboring gene regulator of the transcriptional regulator FhlA Neighboring gene hydrogenase 3 nickel incorporation protein HypA

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Hydrogenase 3 but not hydrogenase 4 is major in hydrogen gas production by Escherichia coli formate hydrogenlyase at acidic pH and in the presence of external formate. Mnatsakanyan N, et al. Cell Biochem Biophys, 2004. PMID 15509886
  2. Microbial reduction of technetium by Escherichia coli and Desulfovibrio desulfuricans: enhancement via the use of high-activity strains and effect of process parameters. Lloyd JR, et al. Biotechnol Bioeng, 1999. PMID 10567070
  3. Reduction and removal of heptavalent technetium from solution by Escherichia coli. Lloyd JR, et al. J Bacteriol, 1997 Mar. PMID 9068649, Free PMC Article
  4. Regulation of gene expression in fermentative and respiratory systems in Escherichia coli and related bacteria. Lin EC, et al. Annu Rev Genet, 1991. PMID 1812811
  5. Regulated expression in vitro of genes coding for formate hydrogenlyase components of Escherichia coli. Hopper S, et al. J Biol Chem, 1994 Jul 29. PMID 8034728

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Hyd-3 has a major role in H2 production at acidic pH independently on the F(0)F(1)-ATPase
    Title: Hydrogenase 3 but not hydrogenase 4 is major in hydrogen gas production by Escherichia coli formate hydrogenlyase at acidic pH and in the presence of external formate.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Process Evidence Code Pubs
involved_in anaerobic electron transport chain IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in anaerobic electron transport chain IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in anaerobic respiration IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in formate oxidation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in formate oxidation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in glucose catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of formate dehydrogenase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of formate dehydrogenase complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
formate hydrogenlyase subunit HycC
NP_417203.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2847415..2849241 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417203.1 formate hydrogenlyase subunit HycC [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417203.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A376D4B0
    Conserved Domains (1) summary
    PRK08042
    Location:16 → 608
    PRK08042; formate hydrogenlyase subunit 3; Reviewed
Nucleotide Protein
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