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gltA citrate synthase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945323, updated on 11-Jun-2025
Official Symbol
gltA
Official Full Name
citrate synthase
Primary source
ECOCYC:EG10402
Locus tag
b0720
See related
ASAP:ABE-0002451
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0709; gluT; icdB
Summary
The Escherichia coli citrate synthase is a type II enzyme, which appears to be unique to the Gram-negative bacteria. [More information is available at EcoCyc: EG10402].
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Sequence:
NC_000913.3 (753185..754468, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative fimbrial usher protein YbgQ Neighboring gene putative fimbrial protein YbgD Neighboring gene protein YbgV Neighboring gene protein YbgU Neighboring gene succinate:quinone oxidoreductase, membrane protein SdhC Neighboring gene succinate:quinone oxidoreductase, membrane protein SdhD

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. The synthesis and use of oligodeoxynucleotides in plasmid DNA sequencing. Ner SS, et al. Int J Biochem, 1986. PMID 3514304
  2. Active site mutants of Escherichia coli citrate synthase. Effects of mutations on catalytic and allosteric properties. Pereira DS, et al. J Biol Chem, 1994 Jan 7. PMID 8276829
  3. Regulation of the citrate synthase (gltA) gene of Escherichia coli in response to anaerobiosis and carbon supply: role of the arcA gene product. Park SJ, et al. J Bacteriol, 1994 Aug. PMID 8051021, Free PMC Article
  4. icdB mutants of Escherichia coli. Helling RB. J Bacteriol, 1995 May. PMID 7730298, Free PMC Article
  5. The binding of propionyl-CoA and carboxymethyl-CoA to Escherichia coli citrate synthase. Man WJ, et al. Biochim Biophys Acta, 1995 Jul 3. PMID 7612655

See all (55) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Engineered citrate synthase alters Acetate Accumulation in Escherichia coli.
    Title: Engineered citrate synthase alters Acetate Accumulation in Escherichia coli.
  2. GltA, icd and mdh do not form a transcription unit, are scattered around the chromosome and are expressed from different promoters.
    Title: Interaction of enzymes of the tricarboxylic acid cycle in Bacillus subtilis and Escherichia coli: a comparative study.
  3. N-terminus verified by Edman degradation on mature peptide
    Title: Changes in protein synthesis as a consequence of heme depletion in Escherichia coli.
  4. For citrate synthase the change in the number of interdomain contacting atoms upon closure remained largely the same, suggesting that the domain faces slide over each other during closure
    Title: Essential dynamics sampling study of adenylate kinase: comparison to citrate synthase and implication for the hinge and shear mechanisms of domain motions.
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Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables NADH binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables acyltransferase activity, acyl groups converted into alkyl on transfer IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables citrate synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within protein hexamerization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in tricarboxylic acid cycle IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol HDA PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
citrate synthase
NP_415248.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    753185..754468 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415248.1 citrate synthase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415248.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A376FSH9, A0A376MTP3, A0A5B9AK54
    Conserved Domains (1) summary
    PRK05614
    Location:1 → 416
    gltA; citrate synthase
Nucleotide Protein
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