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sucD succinyl-CoA synthetase subunit alpha [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945314, updated on 6-Jul-2026
Official Symbol
sucD
Official Full Name
succinyl-CoA synthetase subunit alpha
Primary source
ECOCYC:EG10982
Locus tag
b0729
See related
ASAP:ABE-0002485
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0717
Summary
sucCD is a synthetic lethal with sucAB. [More information is available at EcoGene: EG10982]. contains the his residue that is phosphorylated. [More information is available at EcoCyc: EG10982].
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Sequence:
NC_000913.3 (764180..765049)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene 2-oxoglutarate dehydrogenase E2 subunit Neighboring gene succinyl-CoA synthetase subunit beta Neighboring gene ncRNA Neighboring gene DNA-binding transcriptional repressor MngR

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Functional consequences of substitution of the active site (phospho)histidine residue of Escherichia coli succinyl-CoA synthetase. Majumdar R, et al. Biochim Biophys Acta, 1991 Jan 8. PMID 1986797
  2. Site-directed mutagenesis of Escherichia coli succinyl-CoA synthetase. Histidine 142 alpha is a facilitative catalytic residue. Luo GX, et al. J Biol Chem, 1991 Nov 5. PMID 1939128
  3. Participation of Cys123alpha of Escherichia coli succinyl-CoA synthetase in catalysis. Hidber E, et al. Acta Crystallogr D Biol Crystallogr, 2007 Aug. PMID 17642514
  4. The crystal structure of succinyl-CoA synthetase from Escherichia coli at 2.5-A resolution. Wolodko WT, et al. J Biol Chem, 1994 Apr 8. PMID 8144675
  5. Probing the nucleotide-binding site of Escherichia coli succinyl-CoA synthetase. Joyce MA, et al. Biochemistry, 1999 Jun 1. PMID 10353839

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on mature peptide
    Title: Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12.
  2. explain why this cysteine residue is conserved in the sequences of succinyl-CoA synthetases from different sources
    Title: Participation of Cys123alpha of Escherichia coli succinyl-CoA synthetase in catalysis.
  3. sucAB and sucCD are mutually essential genes for production of succinyl Coa that is essential for cell viability
    Title: sucAB and sucCD are mutually essential genes in Escherichia coli.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables succinate-CoA ligase (ADP-forming) activity EXP
Inferred from Experiment
more info
 PubMed 
enables succinate-CoA ligase (ADP-forming) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables succinate-CoA ligase (ADP-forming) activity IEA
Inferred from Electronic Annotation
more info
  
enables succinate-CoA ligase (GDP-forming) activity EXP
Inferred from Experiment
more info
 PubMed 
enables succinate-CoA ligase (GDP-forming) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables succinate-CoA ligase (GDP-forming) activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within protein autophosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tricarboxylic acid cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tricarboxylic acid cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in tricarboxylic acid cycle NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
part_of succinate-CoA ligase complex IEA
Inferred from Electronic Annotation
more info
  
part_of succinate-CoA ligase complex (ADP-forming) IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of succinate-CoA ligase complex (ADP-forming) IDA
Inferred from Direct Assay
more info
 PubMed 
part_of succinate-CoA ligase complex (ADP-forming) IPI
Inferred from Physical Interaction
more info
 PubMed 
Preferred Names
succinyl-CoA synthetase subunit alpha
NP_415257.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    764180..765049
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415257.1 succinyl-CoA synthetase subunit alpha

    See identical proteins and their annotated locations for NP_415257.1

    Status: REVIEWED

    Conserved Domains (1) summary
    PRK05678
    Location:1 → 289
    PRK05678; succinyl-CoA synthetase subunit alpha; Validated
Nucleotide Protein
Heading Accession and Version

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