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sucC succinyl-CoA synthetase subunit beta [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945312, updated on 4-Feb-2026
Official Symbol
sucC
Official Full Name
succinyl-CoA synthetase subunit beta
Primary source
ECOCYC:EG10981
Locus tag
b0728
See related
ASAP:ABE-0002483
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0716
Summary
sucCD is a synthetic lethal with sucAB. [More information is available at EcoGene: EG10981]. ACTIVE.SITES: [More information is available at EcoCyc: EG10981].
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Sequence:
NC_000913.3 (763014..764180)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene subunit of E1(0) component of 2-oxoglutarate dehydrogenase Neighboring gene 2-oxoglutarate dehydrogenase E2 subunit Neighboring gene succinyl-CoA synthetase subunit alpha Neighboring gene ncRNA

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Novel mechanisms of Escherichia coli succinyl-coenzyme A synthetase regulation. Birney M, et al. J Bacteriol, 1996 May. PMID 8631677, Free PMC Article
  2. Site-directed mutagenesis of Escherichia coli succinyl-CoA synthetase. Histidine 142 alpha is a facilitative catalytic residue. Luo GX, et al. J Biol Chem, 1991 Nov 5. PMID 1939128
  3. Probing the nucleotide-binding site of Escherichia coli succinyl-CoA synthetase. Joyce MA, et al. Biochemistry, 1999 Jun 1. PMID 10353839
  4. Participation of Cys123alpha of Escherichia coli succinyl-CoA synthetase in catalysis. Hidber E, et al. Acta Crystallogr D Biol Crystallogr, 2007 Aug. PMID 17642514
  5. The crystal structure of succinyl-CoA synthetase from Escherichia coli at 2.5-A resolution. Wolodko WT, et al. J Biol Chem, 1994 Apr 8. PMID 8144675

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on complete protein
    Title: Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12.
  2. sucAB and sucCD are mutually essential genes for production of succinyl Coa that is essential for cell viability
    Title: sucAB and sucCD are mutually essential genes in Escherichia coli.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables succinate-CoA ligase (ADP-forming) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables succinate-CoA ligase (ADP-forming) activity IEA
Inferred from Electronic Annotation
more info
  
enables succinate-CoA ligase (ADP-forming) activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables succinate-CoA ligase (GDP-forming) activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in succinyl-CoA metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tricarboxylic acid cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tricarboxylic acid cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within tricarboxylic acid cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tricarboxylic acid cycle NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
part_of succinate-CoA ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of succinate-CoA ligase complex IEA
Inferred from Electronic Annotation
more info
  
part_of succinate-CoA ligase complex (ADP-forming) IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
succinyl-CoA synthetase subunit beta
NP_415256.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    763014..764180
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415256.1 succinyl-CoA synthetase subunit beta

    See identical proteins and their annotated locations for NP_415256.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A2X1PL10, A0A5N3D322, A0A775WV98
    Conserved Domains (1) summary
    PRK00696
    Location:1 → 388
    sucC; ADP-forming succinate--CoA ligase subunit beta
Nucleotide Protein
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