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hisJ histidine ABC transporter periplasmic binding protein [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945309, updated on 25-Jun-2025
Official Symbol
hisJ
Official Full Name
histidine ABC transporter periplasmic binding protein
Primary source
ECOCYC:EG12124
Locus tag
b2309
See related
ASAP:ABE-0007617
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2303
Summary
Overexpression causes abnormal biofilm architecture. [More information is available at EcoGene: EG12124]. HisPMQJ is an ATP-dependent histidine transport system that is a member of the ATP-Binding Cassette (ABC) Superfamily of transporters . [More information is available at EcoCyc: EG12124].
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Sequence:
NC_000913.3 (2426006..2426788, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene lysine/arginine/ornithine ABC transporter/histidine ABC transporter, ATP binding subunit Neighboring gene lysine/arginine/ornithine ABC transporter/histidine ABC transporter, membrane subunit HisM Neighboring gene lysine/arginine/ornithine ABC transporter/histidine ABC transporter, membrane subunit HisQ Neighboring gene lysine/arginine/ornithine ABC transporter periplasmic binding protein Neighboring gene flavin prenyltransferase

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Backbone resonance assignments for the ligand binding subunit of the histidine permease complex (HisJ) from Escherichia coli, under histidine-bound and unbound states. Igarashi S, et al. Biomol NMR Assign, 2010 Apr. PMID 19921465
  2. Crystallization and preliminary X-ray crystallographic data of a histidine-binding protein from Escherichia coli. Trakhanov SD, et al. J Mol Biol, 1989 Jun 20. PMID 2668541
  3. The histidine-binding protein J, a histidine transport component, has two different functional sites. Kustu SG, et al. J Biol Chem, 1974 Nov 10. PMID 4213931
  4. Refined 1.89-A structure of the histidine-binding protein complexed with histidine and its relationship with many other active transport/chemosensory proteins. Yao N, et al. Biochemistry, 1994 Apr 26. PMID 8161536
  5. Ligand binding specificity of the Escherichia coli periplasmic histidine binding protein, HisJ. Paul S, et al. Protein Sci, 2017 Feb. PMID 27865021, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables amino acid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables amino acid binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in L-histidine import across plasma membrane NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within L-histidine transport IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
part_of ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing NAS
Non-traceable Author Statement
more info
 PubMed 
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in outer membrane-bounded periplasmic space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in outer membrane-bounded periplasmic space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in outer membrane-bounded periplasmic space IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
histidine ABC transporter periplasmic binding protein
NP_416812.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2426006..2426788 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416812.1 histidine ABC transporter periplasmic binding protein [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416812.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A376FYU1, A0A8S7I920
    Conserved Domains (1) summary
    PRK15437
    Location:1 → 259
    PRK15437; histidine ABC transporter substrate-binding protein HisJ; Provisional
Nucleotide Protein
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