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sdhB [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945300, updated on 24-Aug-2024

Summary

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Official Symbol
sdhB
Primary source
ASAP:ABE-0002468
Locus tag
b0724
See related
ECOCYC:EG10932
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
dhsB; ECK0713
Summary
The sdhABCD operon is negatively regulated by ryhB RNA as part of indirect positive regulation by Fur. [More information is available at EcoGene: EG10932]. This is one of two catalytic subunits of the four subunit enzyme. [More information is available at EcoCyc: EG10932].
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Genomic context

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Sequence:
NC_000913.3 (757689..758405)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene succinate:quinone oxidoreductase, membrane protein SdhC Neighboring gene succinate:quinone oxidoreductase, membrane protein SdhD Neighboring gene succinate:quinone oxidoreductase, FAD binding protein Neighboring gene subunit of E1(0) component of 2-oxoglutarate dehydrogenase Neighboring gene dihydrolipoyltranssuccinylase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Out of plane distortions of the heme b of Escherichia coli succinate dehydrogenase. Tran QM, et al. PLoS One, 2012. PMID 22393428, Free PMC Article
  2. Evidence that centre 2 in Escherichia coli fumarate reductase is a [4Fe-4S]cluster. Cammack R, et al. Biochim Biophys Acta, 1986 Apr 22. PMID 3008846
  3. The high potential iron-sulfur center in Escherichia coli fumarate reductase is a three-iron cluster. Morningstar JE, et al. J Biol Chem, 1985 Nov 5. PMID 2997176
  4. Magnetic circular dichroism studies of succinate dehydrogenase. Evidence for [2Fe-2S], [3Fe-xS], and [4Fe-4S] centers in reconstitutively active enzyme. Johnson MK, et al. J Biol Chem, 1985 Jun 25. PMID 2987254
  5. Evidence for non-cysteinyl coordination of the [2Fe-2S] cluster in Escherichia coli succinate dehydrogenase. Werth MT, et al. FEBS Lett, 1992 Mar 24. PMID 1312028

See all (83) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SDH and FRD represent a paired system that gives rise to and maintains E. coli antibiotic-resistant persisters by producing and utilizing fumarate, respectively.
    Title: Fumarate-Mediated Persistence of Escherichia coli against Antibiotics.
  2. We demonstrate that the FAD assembly factor SdhE, which flavinylates and activates the respiratory enzyme succinate dehydrogenase (SDH), is also required for the complete activation and flavinylation of fumarate reductase .
    Title: The succinate dehydrogenase assembly factor, SdhE, is required for the flavinylation and activation of fumarate reductase in bacteria.
  3. Out of plane distortions of the heme b of Escherichia coli succinate dehydrogenase
    Title: Out of plane distortions of the heme b of Escherichia coli succinate dehydrogenase.
  4. Data suggest thatthe quinone within the quinone-binding pocket of comolex II is essential for catalysis.
    Title: The quinone-binding and catalytic site of complex II.
  5. N-terminus verified by Edman degradation on complete protein
    Title: Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12.
  6. iron-sulfur clusters in Escherichia coli succinate dehydrogenase direct electron flow
    Title: The iron-sulfur clusters in Escherichia coli succinate dehydrogenase direct electron flow.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 2 iron, 2 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables 2 iron, 2 sulfur cluster binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables 3 iron, 4 sulfur cluster binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables 3 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables 4 iron, 4 sulfur cluster binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables electron transfer activity IEA
Inferred from Electronic Annotation
more info
  
enables electron transfer activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables iron-sulfur cluster binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables succinate dehydrogenase (quinone) activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in aerobic electron transport chain NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in aerobic respiration IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within aerobic respiration IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in respiratory electron transport chain IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tricarboxylic acid cycle IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
part_of respiratory chain complex II (succinate dehydrogenase) IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
succinate:quinone oxidoreductase, iron-sulfur cluster binding protein
NP_415252.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    757689..758405
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415252.1 succinate:quinone oxidoreductase, iron-sulfur cluster binding protein [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415252.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A5B9AAB3, A0A8S7EJ05
    Conserved Domains (1) summary
    PRK05950
    Location:4 → 236
    sdhB; succinate dehydrogenase iron-sulfur subunit; Reviewed
Nucleotide Protein
Heading Accession and Version

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