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nagB glucosamine-6-phosphate deaminase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945290, updated on 30-Jul-2025
Official Symbol
nagB
Official Full Name
glucosamine-6-phosphate deaminase
Primary source
ECOCYC:EG10633
Locus tag
b0678
See related
ASAP:ABE-0002304
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0666; glmD
Summary
Glucosamine-6-phosphate deaminase catalyzes the second cytoplasmic reaction in the metabolism of N-acetyl-D-glucosamine. [More information is available at EcoCyc: EG10633].
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Sequence:
NC_000913.3 (702811..703611, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional dual regulator NagC Neighboring gene N-acetylglucosamine-6-phosphate deacetylase Neighboring gene N-acetylglucosamine-specific PTS enzyme IIABC component Neighboring gene glutamine--tRNA ligase

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Amino sugar assimilation by Escherichia coli. Rolls JP, et al. J Bacteriol, 1972 Nov. PMID 4563983, Free PMC Article
  2. Differential scanning calorimetry of the irreversible denaturation of Escherichia coli glucosamine-6-phosphate deaminase. Hernández-Arana A, et al. Biochemistry, 1993 Apr 13. PMID 8466906
  3. Glucosamine-6-phosphate deaminase from Escherichia coli has a trimer of dimers structure with three intersubunit disulphides. Altamirano MM, et al. Biochem J, 1993 Nov 1. PMID 8240271, Free PMC Article
  4. Spectrochemical evidence for the presence of a tyrosine residue in the allosteric site of glucosamine-6-phosphate deaminase from Escherichia coli. Altamirano MM, et al. Eur J Biochem, 1994 Mar 1. PMID 8125098
  5. Asymmetric allosteric activation of Escherichia coli glucosamine-6-phosphate deaminase produced by replacements of Tyr 121. Altamirano MM, et al. Biochemistry, 1995 May 9. PMID 7742311

See all (61) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. We provide evidence here that NanE, GlcNAc-6P epimerase, and the uridylylated PII protein allosterically activate NagB by direct protein-protein interactions.
    Title: The Nitrogen Regulatory PII Protein (GlnB) and N-Acetylglucosamine 6-Phosphate Epimerase (NanE) Allosterically Activate Glucosamine 6-Phosphate Deaminase (NagB) in Escherichia coli.
  2. Data indicate the existence of tertiary mixed forms at glucosamine-6-phosphate deaminase (EcGNPDA) T conformers.
    Title: The tertiary origin of the allosteric activation of E. coli glucosamine-6-phosphate deaminase studied by sol-gel nanoencapsulation of its T conformer.
  3. strains carrying a wild-type deaminase (nagB) gene, increasing the level of the NagB protein or the rate of GlcN uptake increased the growth rate, which showed that both enzyme induction and sugar transport were limiting.
    Title: Why does Escherichia coli grow more slowly on glucosamine than on N-acetylglucosamine? Effects of enzyme levels and allosteric activation of GlcN6P deaminase (NagB) on growth rates.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables glucosamine-6-phosphate deaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glucosamine-6-phosphate deaminase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glucosamine-6-phosphate deaminase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in N-acetylglucosamine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within N-acetylglucosamine catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in N-acetylglucosamine metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in N-acetylneuraminate catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in N-acetylneuraminate catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within N-acetylneuraminate catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in UDP-N-acetylglucosamine biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glucosamine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
glucosamine-6-phosphate deaminase
NP_415204.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    702811..703611 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415204.1 glucosamine-6-phosphate deaminase

    See identical proteins and their annotated locations for NP_415204.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A2X1NWT2, A0AAN3KVT3
    Conserved Domains (1) summary
    TIGR00502
    Location:1 → 259
    nagB; glucosamine-6-phosphate isomerase
Nucleotide Protein
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