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mprA DNA-binding transcriptional regulator MprA [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945282, updated on 4-Apr-2024

Summary

Gene symbol
mprA
Gene description
DNA-binding transcriptional regulator MprA
Primary source
ASAP:ABE-0008834
Locus tag
b2684
See related
ECOCYC:EG10603
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2678; emrR
Summary
The "Escherichia coli multidrug resistance regulator" , EmrR, negatively regulates the transcription of genes that code for multidrug resistance pumps that extrude structurally unrelated antimicrobial agents from the cell and possibly it also represses a gene that codes for a porin . [More information is available at EcoCyc: EG10603].
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Genomic context

Sequence:
NC_000913.3 (2810770..2811300)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene L-valine exporter, YgaZ component Neighboring gene L-valine exporter, YgaH component Neighboring gene multidrug efflux pump membrane fusion protein EmrA Neighboring gene multidrug efflux pump membrane subunit EmrB

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
DNA-binding transcriptional regulator MprA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2810770..2811300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417169.1 DNA-binding transcriptional regulator MprA [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417169.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A6C9QFV1, W1EUT9
    Conserved Domains (1) summary
    PRK10870
    Location:1176
    PRK10870; transcriptional repressor MprA; Provisional