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ldtA L,D-transpeptidase LdtA [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945273, updated on 25-Jun-2025
Official Symbol
ldtA
Official Full Name
L,D-transpeptidase LdtA
Primary source
ECOCYC:G7073
Locus tag
b1990
See related
ASAP:ABE-0006607
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1985; erfK; yeeG; yzzT
Summary
ErfK family. [More information is available at EcoGene: EG12682]. ErfK is an L,D-transpeptidase responsible removal of the D-alanine residue of peptidoglycan tetrapeptide stems and attachment of the lysine residue of Braun lipoprotein to the meso-diaminopimelyl (DAP) residue of the resulting tripeptide. [More information is available at EcoCyc: G7073].
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Sequence:
NC_000913.3 (2062391..2063323, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional dual regulator Nac Neighboring gene tRNA-Asn Neighboring gene nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Neighboring gene cobalamin 5'-phosphate synthase Neighboring gene cobinamide-P guanylyltransferase/cobinamide kinase

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Identification and characterization of the Escherichia coli stress protein UP12, a putative in vivo substrate of GroEL. Bochkareva ES, et al. Eur J Biochem, 2002 Jun. PMID 12071968
  2. A periplasmic reducing system protects single cysteine residues from oxidation. Depuydt M, et al. Science, 2009 Nov 20. PMID 19965429
  3. Genome-wide analysis of the general stress response network in Escherichia coli: sigmaS-dependent genes, promoters, and sigma factor selectivity. Weber H, et al. J Bacteriol, 2005 Mar. PMID 15716429, Free PMC Article
  4. Identification of the L,D-transpeptidases responsible for attachment of the Braun lipoprotein to Escherichia coli peptidoglycan. Magnet S, et al. J Bacteriol, 2007 May. PMID 17369299, Free PMC Article
  5. High-density microarray-mediated gene expression profiling of Escherichia coli. Wei Y, et al. J Bacteriol, 2001 Jan. PMID 11133948, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on mature peptide
    Title: Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12.
  2. Escherichia coli Ldt(fm) homologues are responsible for the attachment of the Braun lipoprotein to murein
    Title: Identification of the L,D-transpeptidases responsible for attachment of the Braun lipoprotein to Escherichia coli peptidoglycan.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables carboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidoglycan L,D-transpeptidase activity EXP
Inferred from Experiment
more info
 PubMed 
enables peptidoglycan L,D-transpeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in peptidoglycan metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within peptidoglycan-protein cross-linking EXP
Inferred from Experiment
more info
 PubMed 
acts_upstream_of_or_within peptidoglycan-protein cross-linking IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
L,D-transpeptidase LdtA

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2062391..2063323 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416494.1 L,D-transpeptidase LdtA [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416494.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A085P386
    Conserved Domains (1) summary
    PRK10190
    Location:1 → 310
    PRK10190; L,D-transpeptidase; Provisional
Nucleotide Protein
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