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paaI phenylacetyl-CoA thioesterase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945265, updated on 30-Jul-2025
Official Symbol
paaI
Official Full Name
phenylacetyl-CoA thioesterase
Primary source
ECOCYC:G6717
Locus tag
b1396
See related
ASAP:ABE-0004666
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1393; ydbV
Summary
Has a hot-dog fold. [More information is available at EcoGene: EG13743]. PaaI belongs to the hotdog-fold superfamily and the acyl-CoA thioesterase subfamily of enzymes. [More information is available at EcoCyc: G6717].
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Sequence:
NC_000913.3 (1460471..1460893)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene phenylacetyl-CoA 1,2-epoxidase, reductase subunit Neighboring gene putative 2,3-dehydroadipyl-CoA hydratase Neighboring gene putative ring 1,2-epoxyphenylacetyl-CoA isomerase (oxepin-CoA forming) Neighboring gene 3-hydroxyadipyl-CoA dehydrogenase Neighboring gene beta-ketoadipyl-CoA thiolase Neighboring gene phenylacetate-CoA ligase

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Functional genomics by NMR spectroscopy. Phenylacetate catabolism in Escherichia coli. Ismail W, et al. Eur J Biochem, 2003 Jul. PMID 12846838
  2. Transcriptional regulation of the divergent paa catabolic operons for phenylacetic acid degradation in Escherichia coli. Ferrández A, et al. J Biol Chem, 2000 Apr 21. PMID 10766858
  3. Structure, function, and mechanism of the phenylacetate pathway hot dog-fold thioesterase PaaI. Song F, et al. J Biol Chem, 2006 Apr 21. PMID 16464851
  4. Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Hayashi K, et al. Mol Syst Biol, 2006. PMID 16738553, Free PMC Article
  5. The complete genome sequence of Escherichia coli K-12. Blattner FR, et al. Science, 1997 Sep 5. PMID 9278503

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables acyl-CoA hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acyl-CoA hydrolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables acyl-CoA hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables thiolester hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in phenylacetate catabolic process IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
phenylacetyl-CoA thioesterase

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1460471..1460893
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415914.1 phenylacetyl-CoA thioesterase

    See identical proteins and their annotated locations for NP_415914.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A376MXD3, A0A8S7CMT9
    Conserved Domains (1) summary
    TIGR02286
    Location:19 → 132
    PaaD; phenylacetic acid degradation protein PaaD
Nucleotide Protein
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