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paaI [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945265, updated on 24-Aug-2024

Summary

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Official Symbol
paaI
Primary source
ECOCYC:G6717
Locus tag
b1396
See related
ASAP:ABE-0004666
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1393; ydbV
Summary
Has a hot-dog fold. [More information is available at EcoGene: EG13743]. PaaI belongs to the hotdog-fold superfamily and the acyl-CoA thioesterase subfamily of enzymes. [More information is available at EcoCyc: G6717].
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Genomic context

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Sequence:
NC_000913.3 (1460471..1460893)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene phenylacetyl-CoA 1,2-epoxidase, reductase subunit Neighboring gene putative 2,3-dehydroadipyl-CoA hydratase Neighboring gene putative ring 1,2-epoxyphenylacetyl-CoA isomerase (oxepin-CoA forming) Neighboring gene 3-hydroxyadipyl-CoA dehydrogenase Neighboring gene beta-ketoadipyl-CoA thiolase Neighboring gene phenylacetate-CoA ligase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional genomics by NMR spectroscopy. Phenylacetate catabolism in Escherichia coli. Ismail W, et al. Eur J Biochem, 2003 Jul. PMID 12846838
  2. Transcriptional regulation of the divergent paa catabolic operons for phenylacetic acid degradation in Escherichia coli. Ferrández A, et al. J Biol Chem, 2000 Apr 21. PMID 10766858
  3. Catabolism of phenylacetic acid in Escherichia coli. Characterization of a new aerobic hybrid pathway. Ferrández A, et al. J Biol Chem, 1998 Oct 2. PMID 9748275
  4. Structure, function, and mechanism of the phenylacetate pathway hot dog-fold thioesterase PaaI. Song F, et al. J Biol Chem, 2006 Apr 21. PMID 16464851
  5. Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Hayashi K, et al. Mol Syst Biol, 2006. PMID 16738553, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables acyl-CoA hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acyl-CoA hydrolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables acyl-CoA hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables thiolester hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in phenylacetate catabolic process IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
phenylacetyl-CoA thioesterase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1460471..1460893
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415914.1 phenylacetyl-CoA thioesterase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415914.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A376MXD3, A0A8S7CMT9
    Conserved Domains (1) summary
    TIGR02286
    Location:19 → 132
    PaaD; phenylacetic acid degradation protein PaaD
Nucleotide Protein
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