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serA phosphoglycerate dehydrogenase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945258, updated on 4-Feb-2026
Official Symbol
serA
Official Full Name
phosphoglycerate dehydrogenase
Primary source
ECOCYC:EG10944
Locus tag
b2913
See related
ASAP:ABE-0009561
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2909
Summary
D-3-phosphoglycerate dehydrogenase catalyzes the first committed step in the biosynthesis of L-serine. [More information is available at EcoCyc: EG10944].
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Sequence:
NC_000913.3 (3057178..3058410, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene 5-formyltetrahydrofolate cyclo-ligase Neighboring gene ncRNA Neighboring gene toxic peptide IbsC Neighboring gene ribose-5-phosphate isomerase A Neighboring gene pseudo

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. The mechanism of velocity modulated allosteric regulation in D-3-phosphoglycerate dehydrogenase. Site-directed mutagenesis of effector binding site residues. Al-Rabiee R, et al. J Biol Chem, 1996 Sep 20. PMID 8798520
  2. Hybrid tetramers reveal elements of cooperativity in Escherichia coli D-3-phosphoglycerate dehydrogenase. Grant GA, et al. J Biol Chem, 2003 May 16. PMID 12644455
  3. De-regulation of D-3-phosphoglycerate dehydrogenase by domain removal. Bell JK, et al. Eur J Biochem, 2002 Sep. PMID 12199695
  4. Cofactor binding to Escherichia coli D-3-phosphoglycerate dehydrogenase induces multiple conformations which alter effector binding. Grant GA, et al. J Biol Chem, 2002 Oct 18. PMID 12183470
  5. Specific interactions at the regulatory domain-substrate binding domain interface influence the cooperativity of inhibition and effector binding in Escherichia coli D-3-phosphoglycerate dehydrogenase. Grant GA, et al. J Biol Chem, 2001 Jan 12. PMID 11050089

See all (60) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Inhibition of glycine cleavage system by pyridoxine 5'-phosphate causes synthetic lethality in glyA yggS and serA yggS in Escherichia coli.
    Title: Inhibition of glycine cleavage system by pyridoxine 5'-phosphate causes synthetic lethality in glyA yggS and serA yggS in Escherichia coli.
  2. Data indicate that the cooperative transmission induced by serine binding is transmitted through the D-3-phosphoglycerate dehydrogenase Gly294-Gly295 hinge region to the opposite serine binding interface.
    Title: Transient kinetic analysis of L-serine interaction with Escherichia coli D-3-phosphoglycerate dehydrogenase containing amino acid mutations in the hinge regions.
  3. L-serine, inhibitor of D-3-phosphoglycerate dehydrogenase, exerts its effect on at least two steps in the kinetic mechanism, but to very different degrees.
    Title: Transient kinetic analysis of the interaction of L-serine with Escherichia coli D-3-phosphoglycerate dehydrogenase reveals the mechanism of V-type regulation and the order of effector binding.
  4. the rate-limiting step in both directions is a conformational change in the Escherichia coli D-3-phosphoglycerate dehydrogenase enzyme that is not detected optically
    Title: A stopped flow transient kinetic analysis of substrate binding and catalysis in Escherichia coli D-3-phosphoglycerate dehydrogenase.
  5. N-terminus verified by Edman degradation on mature peptide
    Title: Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12.
  6. crystal structure
    Title: Vmax regulation through domain and subunit changes. The active form of phosphoglycerate dehydrogenase.
  7. analysis of mutation effects on effector binding and domain rotation in Escherichia coli D-3-phosphoglycerate dehydrogenase
    Title: The effect of hinge mutations on effector binding and domain rotation in Escherichia coli D-3-phosphoglycerate dehydrogenase.
  8. L-Serine inhibits the catalytic activity of D-3-phosphoglycerate dehydrogenase by binding to its regulatory domain.
    Title: Identification of amino acid residues contributing to the mechanism of cooperativity in Escherichia coli D-3-phosphoglycerate dehydrogenase.
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Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables (R)-2-hydroxyglutarate (NAD+) dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables (S)-2-hydroxyglutarate dehydrogenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables NAD binding IEA
Inferred from Electronic Annotation
more info
  
enables NAD+ binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables NADH binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
enables phosphoglycerate dehydrogenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphoglycerate dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in L-serine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within L-serine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in amino acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
phosphoglycerate dehydrogenase
NP_417388.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3057178..3058410 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417388.1 phosphoglycerate dehydrogenase

    See identical proteins and their annotated locations for NP_417388.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A376ZSW1
    Conserved Domains (1) summary
    PRK11790
    Location:1 → 410
    PRK11790; phosphoglycerate dehydrogenase
Nucleotide Protein
Heading Accession and Version

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