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fhuC [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945250, updated on 11-Sep-2024

Summary

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Official Symbol
fhuC
Primary source
ECOCYC:EG10304
Locus tag
b0151
See related
ASAP:ABE-0000522
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0150
Summary
fhuC mutants are albomycin resistant. [More information is available at EcoGene: EG10304]. The FhuBCD ATP-dependent iron (III) hydroxamate transporter is a member of the ATP-Binding Cassette (ABC) Superfamily of transporters . [More information is available at EcoCyc: EG10304].
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Genomic context

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Sequence:
NC_000913.3 (169778..170575)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene PBP1Bgamma;peptidoglycan glycosyltransferase/peptidoglycan DD-transpeptidase MrcB Neighboring gene ferrichrome outer membrane transporter/phage receptor Neighboring gene iron(III) hydroxamate ABC transporter periplasmic binding protein Neighboring gene iron(III) hydroxamate ABC transporter membrane subunit Neighboring gene glutamate-1-semialdehyde 2,1-aminomutase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Conserved amino acids in the N- and C-terminal domains of integral membrane transporter FhuB define sites important for intra- and intermolecular interactions. Böhm B, et al. Mol Microbiol, 1996 Apr. PMID 8861219
  2. ATP-dependent ferric hydroxamate transport system in Escherichia coli: periplasmic FhuD interacts with a periplasmic and with a transmembrane/cytoplasmic region of the integral membrane protein FhuB, as revealed by competitive peptide mapping. Mademidis A, et al. Mol Microbiol, 1997 Dec. PMID 9426146
  3. fhuC and fhuD genes for iron (III)-ferrichrome transport into Escherichia coli K-12. Coulton JW, et al. J Bacteriol, 1987 Aug. PMID 3301821, Free PMC Article
  4. Iron(III) hydroxamate transport across the cytoplasmic membrane of Escherichia coli. Köster W. Biol Met, 1991. PMID 1830209
  5. Iron(III) hydroxamate transport in Escherichia coli K-12: FhuB-mediated membrane association of the FhuC protein and negative complementation of fhuC mutants. Schultz-Hauser G, et al. J Bacteriol, 1992 Apr. PMID 1551849, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ABC-type ferric hydroxamate transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ABC-type ferric hydroxamate transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding ISM
Inferred from Sequence Model
more info
 PubMed 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ferric iron transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables siderophore uptake transmembrane transporter activity EXP
Inferred from Experiment
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within ferric-hydroxamate import into cell EXP
Inferred from Experiment
more info
 PubMed 
involved_in iron ion import across plasma membrane NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in iron ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in siderophore transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of ATP-binding cassette (ABC) transporter complex TAS
Traceable Author Statement
more info
 PubMed 
part_of ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing NAS
Non-traceable Author Statement
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
iron(III) hydroxamate ABC transporter ATP binding subunit
NP_414693.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    169778..170575
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414693.1 iron(III) hydroxamate ABC transporter ATP binding subunit [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414693.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A376FR97
    Conserved Domains (1) summary
    PRK10575
    Location:1 → 265
    PRK10575; Fe3+-hydroxamate ABC transporter ATP-binding protein FhuC
Nucleotide Protein
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