Format

Send to:

Choose Destination

mrdA peptidoglycan DD-transpeptidase MrdA [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945240, updated on 23-Nov-2021

Summary

Gene symbol
mrdA
Gene description
peptidoglycan DD-transpeptidase MrdA
Primary source
ASAP:ABE-0002178
Locus tag
b0635
See related
ECOCYC:EG10606
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0628; pbpA
Summary
Penicillin binding protein 2 (PBP2) is responsible for maintaining the rod cell shape and mecillinam sensitivity in Escherichia coli along with the product of the mrdB gene, RodA . mrdA and mrdB share a transcription unit . [More information is available at EcoCyc: EG10606].
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Sequence:
NC_000913.3 (666316..668217, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene rare lipoprotein RlpA Neighboring gene SEDS family protein MrdB Neighboring gene 23S rRNA m(3)psi1915 methyltransferase Neighboring gene ribosomal silencing factor RsfS

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables carboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables penicillin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables penicillin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables penicillin binding IEA
Inferred from Electronic Annotation
more info
 
enables penicillin binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidoglycan L,D-transpeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables peptidoglycan L,D-transpeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables serine-type D-Ala-D-Ala carboxypeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables serine-type D-Ala-D-Ala carboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables serine-type D-Ala-D-Ala carboxypeptidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables serine-type D-Ala-D-Ala carboxypeptidase activity ISM
Inferred from Sequence Model
more info
PubMed 
Process Evidence Code Pubs
involved_in cell wall organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell wall organization IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell wall organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within peptidoglycan biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in peptidoglycan biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within peptidoglycan biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cell shape IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of cell shape IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to antibiotic IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of plasma membrane ISM
Inferred from Sequence Model
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in outer membrane-bounded periplasmic space ISM
Inferred from Sequence Model
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
peptidoglycan DD-transpeptidase MrdA

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    666316..668217 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415168.1 Peptide Sequence

    See identical proteins and their annotated locations for NP_415168.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P0AD65
    Conserved Domains (1) summary
    PRK10795
    Location:1632
    PRK10795; penicillin-binding protein 2; Provisional
Support Center