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pheP phenylalanine:H(+) symporter PheP [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945199, updated on 25-Jun-2025
Official Symbol
pheP
Official Full Name
phenylalanine:H(+) symporter PheP
Primary source
ECOCYC:EG10708
Locus tag
b0576
See related
ASAP:ABE-0001976
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0568
Summary
The pheP GTG start was verified by start codon mutagenesis (Pi, 1991). [More information is available at EcoGene: EG10708]. PheP is a phenylalanine transporter that is a member of the Amino Acid-Polyamine-Organocation (APC) Superfamily of transporters . [More information is available at EcoCyc: EG10708].
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Sequence:
NC_000913.3 (601959..603335)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene copper/silver export system membrane fusion protein Neighboring gene copper/silver export system RND permease Neighboring gene miniconductance mechanosensitive channel YbdG Neighboring gene NAD(P)H-dependent nitroreductase NfsB

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Putative interhelical interactions within the PheP protein revealed by second-site suppressor analysis. Dogovski C, et al. J Bacteriol, 2003 Nov. PMID 14563856, Free PMC Article
  2. Topology of the phenylalanine-specific permease of Escherichia coli. Pi J, et al. J Bacteriol, 1996 May. PMID 8626334, Free PMC Article
  3. Site-directed mutagenesis reveals the importance of conserved charged residues for the transport activity of the PheP permease of Escherichia coli. Pi J, et al. J Bacteriol, 1993 Nov. PMID 8226700, Free PMC Article
  4. Reversible topological organization within a polytopic membrane protein is governed by a change in membrane phospholipid composition. Zhang W, et al. J Biol Chem, 2003 Dec 12. PMID 14525982
  5. A study of AroP-PheP chimeric proteins and identification of a residue involved in tryptophan transport. Cosgriff AJ, et al. J Bacteriol, 2000 Apr. PMID 10735864, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within phenylalanine transport EXP
Inferred from Experiment
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
phenylalanine:H(+) symporter PheP

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    601959..603335
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415108.1 phenylalanine:H(+) symporter PheP [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415108.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A376FPT9
    Conserved Domains (1) summary
    PRK10249
    Location:1 → 458
    PRK10249; phenylalanine transporter; Provisional
Nucleotide Protein
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